1: 98 percent / sodium hydroxide / methanol; H2O / 3 h / Ambient temperature 2: 95 percent / tetrahydrofuran / 12 h 3: 87 percent / lithium hexamethyldisilazide / tetrahydrofuran; hexane / 7 h / -78 °C 4: 95 percent / lithium hexamethyldisilazide / tetrahydrofuran; hexane / 2 h / -78 °C 5: m-chloroperoxybenzoic acid, 30percent aq. hydrogen peroxide / CDCl3 / 1.) -50 deg C, 15 min, 2.) 0 deg C, 15 min 6: 37 percent / toluene / 5 h / 100 °C 7: 98 percent / sodium hydroxide / H2O; methanol / 2 h / 0 °C 8: 98 percent / lithium di-isopropylamide / tetrahydrofuran; hexane / 2 h 9: 78 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 °C 10: 68 percent / pyridine, 30percent aq. hydrogen peroxide / CH2Cl2 / 12 h / Ambient temperature 11: 72 percent / sodium borohydride / ethanol / 3 h / 0 °C 12: 94 percent / pyridine, 4-dimethylaminopyridine / CH2Cl2 / 2 h / Ambient temperature 13: 19 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 1.) -20 deg C, 1 h, 2.) 0 deg C, 12 h 14: 67 percent / aluminium isopropoxide / o-xylene / 5 h / 125 °C 15: 40 percent / 5percent aq. HF / acetonitrile / 3 h / Ambient temperature View Scheme

Multi-step reaction with 10 steps 1: 95 percent / N-chlorosuccinimide, Me2S, Et3N / CH2Cl2 / -20 °C2: 70 percent3: 85 percent / Et2N-i-Pr4: 70 percent / Dowex 50W-X8 5: 95 percent / H2 / Pd/C / methanol6: 90 percent / DMSO, oxalyl chloride7: 70 percent8: 1.) 9-BBN, 2.) H2O2, base9: 90 percent / DMSO, oxalyl chloride  

Multi-step reaction with 9 steps 1: 70 percent2: 85 percent / Et2N-i-Pr3: 70 percent / Dowex 50W-X8 4: 95 percent / H2 / Pd/C / methanol5: 90 percent / DMSO, oxalyl chloride6: 70 percent7: 1.) 9-BBN, 2.) H2O2, base8: 90 percent / DMSO, oxalyl chloride  

Multi-step reaction with 8 steps 1: 85 percent / Et2N-i-Pr2: 70 percent / Dowex 50W-X8 3: 95 percent / H2 / Pd/C / methanol4: 90 percent / DMSO, oxalyl chloride5: 70 percent6: 1.) 9-BBN, 2.) H2O2, base7: 90 percent / DMSO, oxalyl chloride  

Multi-step reaction with 6 steps 1: 95 percent / H2 / Pd/C / methanol2: 90 percent / DMSO, oxalyl chloride3: 70 percent4: 1.) 9-BBN, 2.) H2O2, base5: 90 percent / DMSO, oxalyl chloride  

Multi-step reaction with 7 steps 1: 70 percent / Dowex 50W-X8 2: 95 percent / H2 / Pd/C / methanol3: 90 percent / DMSO, oxalyl chloride4: 70 percent5: 1.) 9-BBN, 2.) H2O2, base6: 90 percent / DMSO, oxalyl chloride  

Multi-step reaction with 13 steps 1: 90 percent / LiAlH4 2: 95 percent / MCPBA3: 60 percent / LiAlH4 4: 95 percent / N-chlorosuccinimide, Me2S, Et3N / CH2Cl2 / -20 °C5: 70 percent6: 85 percent / Et2N-i-Pr7: 70 percent / Dowex 50W-X8 8: 95 percent / H2 / Pd/C / methanol9: 90 percent / DMSO, oxalyl chloride10: 70 percent11: 1.) 9-BBN, 2.) H2O2, base12: 90 percent / DMSO, oxalyl chloride  

With  sodium hydroxide in  methanol; water 3 h;  Ambient temperature;