(R)-3-羟基吡咯烷盐酸盐合成路线 （共 18 条）
反应条件
1: in butanone; cyclohexanol T=45 - 154°C; 5 h; 2: With hydrogenchloride in ethyl acetate; butanone; cyclohexanol T=0 - 25°C; pH=1.0 - 2.0; 2 - 3 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/100651 A2, 2008 ;
Location in patent: Page/Page column 15; 32-33 ;
反应条件
hydrogenchloride in methanol; water T=20°C;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: EP1953163 A1, 2008 ;
Location in patent: Page/Page column 20 ;
EP 1953163 A1
反应条件
potassium carbonate in ethanol; nitrogen; water
参考文献
Ayers, Timothy A.; D'Netto, Geoffrey A.; Kubiak, Gregory G.; Mencel, James J.; O'Brien, Michael K.; Powers, Matthew R.; Shay, John J.; Sledeski, Adam W.; Teager, David S.; Vanasse, Benoit
Patent: US2003/69423 A1, 2003 ;
反应条件
hydrogenchloride 6 h; Heating;
参考文献
Yamazaki; Horikawa; Nishitani; Iwasaki
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 7 p. 2024 - 2026
参考文献
US5281601 A1, ;
US 5281601 A
反应条件
sodium hydroxide; sodium chloride in water
参考文献
Warner-Lambert Company
Patent: US4851418 A1, 1989 ;
反应条件
sodium hydroxide; formic acid in tetrahydrofuran; water T=60°C; 2.33333 h; Heating / reflux;
参考文献
Wu; Mori; Buchwald; Bodor, Nicholas
Pharmazie, 2008 , vol. 63, # 3 p. 200 - 209
反应条件
potassium carbonate in tetrahydrofuran; water
参考文献
Kaneka Corporation
Patent: EP1947083 A1, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
triethylamine in water
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US5102877 A1, 1992 ;
