2-氧代环戊烷羧酸甲酯合成路线 （共 119 条）
反应条件
sodium hydride; lithium chloride 1.) THF, 0 deg C, 30 min; 2.) RT, overnight; 3.) H2O, DMSO, 160 deg C, 8 h; Yield given. Multistep reaction;
参考文献
Buechi, George; Chu, Ping-Sun
Tetrahedron, 1981 , vol. 37, # 25 p. 4509 - 4514
反应条件
2: tributylstannane / benzene / Heating View Scheme
参考文献
Dowd, Paul; Choi, Soo-Chang
Tetrahedron, 1989 , vol. 45, # 1 p. 77 - 90
反应条件
1: 95 percent / sodium hydride / dimethylformamide 2: 88 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH2Cl2 / 5 h / Heating 3: neat (no solvent) / pyrolysis 4: 75.4 percent / toluene-p-sulphonic acid monohydrate / 24 h / Heating 5: water / stannic chloride / CH2Cl2 View Scheme
参考文献
Evans, Elizabeth H.; Hewson, Alan T.; March, Lorraine A.; Nowell, Ian W.; Wadsworth, Alan H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 137 - 150
反应条件
1: 1.) NaH; 3.) LiCl / 1.) THF, 0 deg C, 30 min; 2.) RT, overnight; 3.) H2O, DMSO, 160 deg C, 8 h 2: 2.) I2 / 1.) Et2O, r. t., 4 h; 2.) 100 deg C, 2-4 h View Scheme
参考文献
Buechi, George; Chu, Ping-Sun
Tetrahedron, 1981 , vol. 37, # 25 p. 4509 - 4514
反应条件
1: 80 percent / K2CO3, NaI / acetone / 48 h / Heating 2: 90 percent / LiCl / dimethylformamide / 10 h / Heating View Scheme
参考文献
Yadav, Veejendra K.; Kapoor, Kamal K.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 1 p. 8 - 13
反应条件
Schwartz's reagent; lithium hexamethyldisilazane 2.) DME, r.t., 2 h; Yield given. Multistep reaction;
参考文献
Naito, Takeaki; Tanada, Hiromi; Suzuki, Yumiko; Saito, Haruko; Kiguchi, Toshiko; Ninomiya, Ichiya
Heterocycles, 1993 , vol. 36, # 10 p. 2345 - 2366
反应条件
Bi(NO3)3·5H2O T=80°C; Pechmann Condensation;
参考文献
Chen, Yin; Lan, Yu; Wang, Songlin; Zhang, Heng; Xu, Xiangqing; Liu, Xin; Yu, Minquan; Liu, Bi-Feng; Zhang, Guisen
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 427 - 439
反应条件
1: potassium tert-butylate / tert-butyl alcohol / |Reflux 2: trichlorophosphate / 3 h / |Reflux View Scheme
参考文献
Gangjee, Aleem; Zhao, Ying; Raghavan, Sudhir; Rohena, Cristina C.; Mooberry, Susan L.; Hamel, Ernest
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6829 - 6844
反应条件
bromine in diethyl ether
参考文献
Pinacho Crisostomo, Fernando R.; Feng, Yongmei; Zhu, Xuejun; Welsh, Kate; An, Jing; Reed, John C.; Huang, Ziwei
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 22 p. 6413 - 6418
反应条件
1: 8.25 g / K2CO3 / acetone / 19 h / Heating
2: 87 percent / LiI / dimethylformamide / 0.83 h / 150 °C
3: 1.) Et33N, NaI, trimethylsilyl chloride, 2.) HgCl2, hexamethyldisilazane, 3.) NaI, aq. HCl / 1) CH3CN, rt, 45 min; 2) CH2Cl2, THF, rt, 120 min; 3) CH2Cl2, THF, 0 deg C, 15 h
View Scheme
参考文献
Hashizume, Yoshinobu; Maki, Shojiro; Ohashi, Mamoru; Niwa, Haruki
Synthetic Communications, 1999 , vol. 29, # 7 p. 1223 - 1233
