2-氧代环戊烷羧酸甲酯合成路线 （共 119 条）
反应条件
1: 95 percent / sodium hydride / dimethylformamide
2: 88 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH2Cl2 / 5 h / Heating
3: neat (no solvent) / pyrolysis
View Scheme
参考文献
Evans, Elizabeth H.; Hewson, Alan T.; March, Lorraine A.; Nowell, Ian W.; Wadsworth, Alan H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 137 - 150
反应条件
sodium hydride
1.)THF,30 min, 2.)reflux, 12 h; Yield given. Multistep reaction;
参考文献
McBride, Bill J.; Garst, Michael E.; Hopkins, Mark
Journal of Organic Chemistry, 1984 , vol. 49, p. 1824 - 1825
反应条件
Reaktion ueber mehrere Stufen;
参考文献
Koetz; Schueler
Justus Liebigs Annalen der Chemie, 1906 , vol. 350, p. 225
反应条件
1: 95 percent / sodium hydride / dimethylformamide
2: 88 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / CH2Cl2 / 5 h / Heating
3: neat (no solvent) / pyrolysis
4: 75.4 percent / toluene-p-sulphonic acid monohydrate / 24 h / Heating
5: water / stannic chloride / CH2Cl2
6: 97 percent / triethylamine / 1 h
7: stannic chloride
View Scheme
参考文献
Evans, Elizabeth H.; Hewson, Alan T.; March, Lorraine A.; Nowell, Ian W.; Wadsworth, Alan H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 137 - 150
反应条件
zinc in toluene
48 h; Reflux;
参考文献
MARS, INCORPORATED; VAN ZANDT, Michael; JAGDMANN, JR., Gunnar Erik
Patent: WO2013/158262 A1, 2013 ;
Location in patent: Paragraph 0048 ;
反应条件
1: 1.) NaH; 3.) LiCl / 1.) THF, 0 deg C, 30 min; 2.) RT, overnight; 3.) H2O, DMSO, 160 deg C, 8 h
2: 2.) I2 / 1.) Et2O, r. t., 4 h; 2.) 100 deg C, 2-4 h
View Scheme
参考文献
Buechi, George; Chu, Ping-Sun
Tetrahedron, 1981 , vol. 37, # 25 p. 4509 - 4514
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2006/35061 A1, 2006 ;
Location in patent: Page/Page column 37; 38 ;
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in cyclohexane
Heating;
参考文献
Ribeiro, Rodrigo S.; De Souza, Rodrigo O. M. A.; Vasconcellos, Mario L. A. A.; Oliveira, Bianca L.; Ferreira, Leonardo C.; Aguiar, Lucia C. S.
Synthesis, 2007 , # 1 p. 61 - 64
反应条件
1: methyl 2-oxo-cyclopentane-1-carboxylate With sodium hydride in tetrahydrofuran
T=0°C; 0.2 h;
2: 1-bromo-pent-2-yne in tetrahydrofuran
T=20°C; 2 h; Further stages.;
参考文献
Shintani, Ryo; Duan, Wei-Liang; Park, Soyoung; Hayashi, Tamio
Chemical Communications, 2006 , # 34 p. 3646 - 3647
反应条件
potassium tert-butylate
1.) DMF, 90 deg C; Multistep reaction;
参考文献
Trost, Barry M.; Cossy, Janine; Burks, John
Journal of the American Chemical Society, 1983 , vol. 105, # 4 p. 1052 - 1054
