2-溴-4-氟-6-硝基苯胺合成路线 （共 10 条）
反应条件
hydrogen bromide; bromine in water
参考文献
Merrell Pharmaceuticals Inc.
Patent: US5606063 A1, 1997 ;
US 5606063 A
反应条件
potassium iodide; sulfuric acid; sodium nitrite in water; ethyl acetate
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US5360814 A1, 1994 ;
US 5360814 A
反应条件
copper(I) oxide; sulfuric acid; hypophosphorous acid; sodium nitrite 1.) H2O, -2 deg C - -3 deg C, 105 min, 2.) H2O, -5 deg C, 90 min; 0 deg C, 10 min; Yield given. Multistep reaction;
参考文献
Alagille, David; Dacosta, Herve; Chen, Yelin; Hemstapat, Kamondanai; Rodriguez, Alice; Baldwin, Ronald M.; Conn, Jeffrey P.; Tamagnan, Gilles D.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3243 - 3247
反应条件
sulfuric acid; sodium nitrite in ethanol; water
参考文献
Kanebo, Ltd.
Patent: US5087640 A1, 1992 ;
反应条件
1: 1.) conc. H2SO4, NaNO2, 2.) 50percent H3PO2, Cu2O / 1.) H2O, -2 deg C - -3 deg C, 105 min, 2.) H2O, -5 deg C, 90 min; 0 deg C, 10 min 2: 63 percent / dimethylformamide / 5 h / Heating 3: 92 percent / 75percent H2SO4 / H2O / 2 h / 150 °C View Scheme
参考文献
Adams; Rinehart
Journal of Antibiotics, 1994 , vol. 47, # 12 p. 1456 - 1465
反应条件
1: 1.) H2SO4, NaNO2, 2.) FeSO4*7H2O / 2.) EtOH 2: Fe, NH4Cl View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 23 p. 3397 - 3402
反应条件
1: 1.) conc. H2SO4, NaNO2, 2.) 50percent H3PO2, Cu2O / 1.) H2O, -2 deg C - -3 deg C, 105 min, 2.) H2O, -5 deg C, 90 min; 0 deg C, 10 min 2: 63 percent / dimethylformamide / 5 h / Heating View Scheme
参考文献
Adams; Rinehart
Journal of Antibiotics, 1994 , vol. 47, # 12 p. 1456 - 1465
反应条件
1: tin(ll) chloride / ethanol / 5 h / |Reflux 2: 110 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
WO 2013/026914 A1
反应条件
tin(ll) chloride in ethanol 5 h; Reflux;
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
Location in patent: Page/Page column 118 ;
WO 2013/026914 A1
反应条件
sodium hydrogencarbonate in ethanol; ethyl acetate
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
