diazomethyl-trimethyl-silane in diethyl ether; dichloromethane T=20°C; 0.583333 h;

triethylamine in diethyl ether T=0°C; 6 h; Yield given. Yields of byproduct given;

1: With disodium hydrogenphosphate in ethyl acetate T=50°C; 2: With boron trifluoride diethyl etherate regioselective reaction;

1.1: triethylamine / 1,2-dichloro-ethane / 20 °C 2.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / acetonitrile / 35 °C / sodium phosphate buffer 2.2: 20 °C 3.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.58 h / 20 °C View Scheme

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C 2.1: triethylamine / 1,2-dichloro-ethane / 20 °C 3.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / acetonitrile / 35 °C / sodium phosphate buffer 3.2: 20 °C 4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.58 h / 20 °C View Scheme

1.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / acetonitrile / 35 °C / sodium phosphate buffer 1.2: 20 °C 2.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.58 h / 20 °C View Scheme

Multistep reaction;

Multistep reaction;