sodium tetrahydroborate in ethanol; water T=45°C; 1 h;

1: With dimethylsulfide borane complex; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole in dichloromethane T=-10 - 10°C; 2: With hydrogenchloride; dihydrogen peroxide in methanol; water 3: With sodium hydrogencarbonate in water

1: With water; sodium hydroxide T=80 - 85°C; 1 h; 2: in water Acidic conditions;

sodium carbonate in 2-methyl tetrahydrofuran T=30°C; pH=6.8 - 7.3; Aqueous phosphate bufferEnzymatic reaction;

1: Licarbazepine With pyridine in ethyl acetate T=25 - 35°C; 0.25 h; 2: 2,5-dioxotetrahydrofuran-3,4-diyldiacetate in ethyl acetate T=30 - 35°C; 1 h; Overall yield = 77.08 percent; Overall yield = 0.7 g; Further stages;

1: pyridine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C 2: sodium carbonate / 2-methyl tetrahydrofuran / 30 °C / pH 6.8 - 7.3 / Aqueous phosphate buffer; Enzymatic reaction View Scheme

chiralcel OD-H column in ethanol; hexane; isopropyl alcohol T=25°C; Resolution of racemate;