water; sodium hydroxide in methanol; dichloromethane T=25 - 30°C; 4 h; Product distribution / selectivity;

chiralcel OD-H column in ethanol; hexane; isopropyl alcohol T=25°C; Resolution of racemate;

1: sodium carbonate / 2-methyl tetrahydrofuran / 30 °C / pH 6.8 - 7.3 / Aqueous phosphate buffer; Enzymatic reaction 2: sodium hydroxide; water / ethanol; 2-methyl tetrahydrofuran View Scheme

1: potassium permanganate on alumina; sodium carbonate; AcOOH; acetic acid / dichloromethane / 1.67 h / |Reflux 2: ammonium formate; palladium 10 on activated carbon / dichloromethane; methanol; water / 1 h / 20 °C / |Inert atmosphere 3: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 1 h / |Reflux 4: sodium hydroxide / water / 1 h / 80 - 85 °C View Scheme

1: ammonium formate; palladium 10 on activated carbon / dichloromethane; methanol; water / 1 h / 20 °C / |Inert atmosphere 2: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 1 h / |Reflux 3: sodium hydroxide / water / 1 h / 80 - 85 °C View Scheme