(4-(二(2-氯乙基)氨基)苯基)乙酸合成路线 （共 8 条）
反应条件
dicyclohexyl-carbodiimide in pyridine 30 h; Ambient temperature;
参考文献
Pairas; Camoutsis Ch.; Catsoulacos
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 287 - 288
反应条件
dicyclohexyl-carbodiimide in pyridine 30 h; Ambient temperature;
参考文献
Pairas; Camoutsis Ch.; Catsoulacos
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 287 - 288
反应条件
dicyclohexyl-carbodiimide in pyridine 24 h; Ambient temperature;
参考文献
Pairas; Camoutsis Ch.; Catsoulacos
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 287 - 288
反应条件
1: 8.5 g / H2 / 30percent Pd/C / ethyl acetate
2: 2.9 percent / acetic acid; H2O / 48 h / Ambient temperature
3: 1.65 g / MeSO2Cl, pyridine / 1 h / 80 °C
4: 48 percent / trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Dowell, Robert I.; Springer, Caroline J.; Davies, David H.; Hadley, Elizabeth M.; Burke, Philip J.; Boyle, F. Thomas; Melton, Roger G.; Connors, Thomas A.; Blakey, David C.; Mauger, Anthony B.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1100 - 1105
反应条件
1: 2.9 percent / acetic acid; H2O / 48 h / Ambient temperature
2: 1.65 g / MeSO2Cl, pyridine / 1 h / 80 °C
3: 48 percent / trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Dowell, Robert I.; Springer, Caroline J.; Davies, David H.; Hadley, Elizabeth M.; Burke, Philip J.; Boyle, F. Thomas; Melton, Roger G.; Connors, Thomas A.; Blakey, David C.; Mauger, Anthony B.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 5 p. 1100 - 1105
反应条件
1: CaCO3 / H2O / Heating
2: POCl3 / 0 deg C to RT; reflux
3: conc. hydrochloric acid / 1 h / Heating
View Scheme
参考文献
Hovinen, Jari
Acta Chemica Scandinavica, 1996 , vol. 50, # 12 p. 1174 - 1176
反应条件
1: benzene
2: concentrated aqueous HCl
View Scheme
参考文献
Everett et al.
Journal of the Chemical Society, 1953 , p. 2386,2387
反应条件
sodium hydrogencarbonate
T=20°C; 3 h;
参考文献
Degutene, A.; Dzhyuvene, D.; Shukyalene, D.; Degutis, Yu.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 10 p. 1968 - 1972
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 10 p. 2191 - 2197
