2-己基-3-羟基-5-[(四氢-2H-吡喃-2-基)氧基]十六烷酸合成路线 (共 5 条)
反应条件
benzenesulfonyl chloride in pyridine T=0°C; 0.25 h; Yield given;
参考文献
Hoffmann-La Roche Inc.
Patent: US4931463 A1, 1990 ;
US 4931463 A
反应条件
1: benzenesulfonyl chlorid / pyridine / 0.25 h / 0 °C 2: pyridinium p-toluenesulfonate / ethanol / 4 h / 55 °C 3: 26 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Barbier; Schneider
Helvetica Chimica Acta, 1987 , vol. 70, # 1 p. 196 - 202
反应条件
With sodium hydroxide in methanol; water 4 h; Heating;
参考文献
Barbier; Schneider Helvetica Chimica Acta, 1987 , vol. 70, # 1 p. 196 - 202
反应条件
Multi-step reaction with 3 steps 1: 94 percent / TsOH / CH2Cl2 / 0 degC, 30 min, room t., 1 h2: 0.67 g / NaBH4 / methanol; tetrahydrofuran / 1 h / Ambient temperature3: 0.61 g / NaOH / H2O; methanol / 4 h / Heating
参考文献
Barbier; Schneider Helvetica Chimica Acta, 1987 , vol. 70, # 1 p. 196 - 202
反应条件
Multi-step reaction with 2 steps 1: 0.67 g / NaBH4 / methanol; tetrahydrofuran / 1 h / Ambient temperature2: 0.61 g / NaOH / H2O; methanol / 4 h / Heating
参考文献
Barbier; Schneider Helvetica Chimica Acta, 1987 , vol. 70, # 1 p. 196 - 202