3-己基四氢-4-羟基-6-十一烷基-2H-吡喃-2-酮合成路线 （共 26 条）
反应条件
1: Jones' reagent / acetone / 1 h / 10 °C 2: 84 percent / H2 / PtO2 / ethyl acetate / 48 h / 37503 Torr / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 6 p. 1218 - 1221
反应条件
1.1: copper(II) diacetate / aq. methanol 1.2: NaH; KI; Bu4NBr / tetrahydrofuran / Heating 2.1: NaH; BuLi / tetrahydrofuran / 0 °C 2.2: tetrahydrofuran / Heating 3.1: H2 / (R)-[BINAP-Ru(II)Cl-p-cymene](1+)*Cl(1-) / methanol / 18 h / 60 °C / 76005.1 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 20 p. 3873 - 3875
反应条件
1.1: NaH; BuLi / tetrahydrofuran / 0 °C 1.2: tetrahydrofuran / Heating 2.1: copper(II) diacetate / aq. methanol 2.2: NaH; KI; Bu4NBr / tetrahydrofuran / Heating 3.1: H2 / (R)-[BINAP-Ru(II)Cl-p-cymene](1+)*Cl(1-) / methanol / 18 h / 60 °C / 76005.1 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 20 p. 3873 - 3875
反应条件
1.1: copper(II) diacetate / aq. methanol 1.2: NaH; KI; Bu4NBr / tetrahydrofuran / Heating 2.1: H2 / (R)-[BINAP-Ru(II)Cl-p-cymene](1+)*Cl(1-) / methanol / 18 h / 60 °C / 76005.1 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 20 p. 3873 - 3875
反应条件
1.1: NaH; BuLi / tetrahydrofuran / 0 °C 1.2: tetrahydrofuran / Heating 2.1: H2 / (R)-[BINAP-Ru(II)Cl-p-cymene](1+)*Cl(1-) / methanol / 18 h / 60 °C / 76005.1 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 20 p. 3873 - 3875
反应条件
pyridinium p-toluenesulfonate in toluene T=50°C; 2 h;
参考文献
Tetrahedron Letters, , vol. 45, # 20 p. 3873 - 3875
反应条件
1: H2 / (R)-[BINAP-Ru(II)Cl-p-cymene](1+)*Cl(1-) / methanol / 18 h / 60 °C / 76005.1 Torr 2: PPTS / toluene / 2 h / 50 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 20 p. 3873 - 3875
反应条件
1: 88 percent / pyridinium p-toluenesulfonate / ethanol / 2 h / 50 - 55 °C 2: 1.) 1 N KOH, 2.) p-TsOH / 1.) dioxane, water, RT, overnight, 2.) chloroform, RT, 2 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 6 p. 1218 - 1221
反应条件
1: benzenesulfonylchloride, pyridine / 0 °C 2: 88 percent / pyridinium p-toluenesulfonate / ethanol / 2 h / 50 - 55 °C 3: 1.) 1 N KOH, 2.) p-TsOH / 1.) dioxane, water, RT, overnight, 2.) chloroform, RT, 2 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 6 p. 1218 - 1221
反应条件
1: potassium hydrogencarbonate; 4-(N,N-dimethlyamino)pyridine / water; methanol; toluene / 3.5 h / 11 °C 2: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / 22.5 h / 60 °C 3: hydrogen View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 3 p. 524 - 533
