sodium methylate T=-20°C; 0.5 h;

Multi-step reaction with 2 steps 1: triethylamine / acetonitrile / -15 deg C, 1h, then 20 deg C, 2 h, then 50 deg C, 12 h2: 71 percent / p-toluenesulfonic acid, NaI / H2O; CHCl3 / 4 h / 0 °C  

Multi-step reaction with 3 steps 1: 95 percent / 0.05N H2SO4 / H2O / 5 h / 50 °C2: triethylamine / acetonitrile / -15 deg C, 1h, then 20 deg C, 2 h, then 50 deg C, 12 h3: 71 percent / p-toluenesulfonic acid, NaI / H2O; CHCl3 / 4 h / 0 °C  

Multi-step reaction with 2 steps 1: triethylamine / methanol / 1 h / 20 °C2: 71 percent / p-toluenesulfonic acid, NaI / H2O; CHCl3 / 4 h / 0 °C