(3S,5Z,7E,14Xi,22E)-3-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-9,10-开环麦角甾-5,7,10,22-四烯合成路线 （共 12 条）
反应条件
1: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating 2: imidazole / dimethylformamide / 1.5 h / 20 °C 3: liq. SO2 / diethyl ether / 0.5 h / Heating 4: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 5: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Calverley
Tetrahedron, 1987 , vol. 43, # 20 p. 4609-4619
反应条件
1: 54.9 g / SeO2, 4-methylmorpholine N-oxide / methanol / 5.5 h / Heating 2: imidazole / CH2Cl2 / 6 h / Ambient temperature View Scheme
参考文献
Calverley
Tetrahedron, 1987 , vol. 43, # 20 p. 4609-4619
