(叔丁基)[(3beta,5E,7E,22E)-9,10-开环麦角甾-5,7,10(19),22-四烯-3-基氧基]二甲基硅烷合成路线 （共 7 条）
反应条件
Multi-step reaction with 2 steps 1: imidazole / Ambient temperature2: 94 percent / NaHCO3 / aq. ethanol / 1.25 h / Heating
参考文献
Choudhry, Satish C.; Belica, Peter S.; Coffen, David L.; Focella, Antonino; Maehr, Hubert; et al. Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1496 - 1500
反应条件
Multi-step reaction with 3 steps 1: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating2: imidazole / dimethylformamide / 1.5 h / 20 °C3: liq. SO2 / diethyl ether / 0.5 h / Heating
参考文献
Calverley Tetrahedron, 1987 , vol. 43, # 20 p. 4609-4619
反应条件
Multi-step reaction with 4 steps 1: 54.9 g / SeO2, 4-methylmorpholine N-oxide / methanol / 5.5 h / Heating2: imidazole / CH2Cl2 / 6 h / Ambient temperature3: 63.8 g / SO2 / CH2Cl2 / 0.75 h / -10 °C4: 1) O3, 2) Ph3P / 1) CH2Cl2, MeOH, -10 deg C, 40 min, 2) room temperature, 3 h
参考文献
Choudhry, Satish C.; Belica, Peter S.; Coffen, David L.; Focella, Antonino; Maehr, Hubert; et al. Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1496 - 1500
反应条件
Multi-step reaction with 3 steps 1: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating2: imidazole / dimethylformamide / 1.5 h / 20 °C3: liq. SO2 / diethyl ether / 0.5 h / Heating
参考文献
Calverley Tetrahedron, 1987 , vol. 43, # 20 p. 4609-4619
反应条件
Multi-step reaction with 4 steps 1: 54.9 g / SeO2, 4-methylmorpholine N-oxide / methanol / 5.5 h / Heating2: imidazole / CH2Cl2 / 6 h / Ambient temperature3: 63.8 g / SO2 / CH2Cl2 / 0.75 h / -10 °C4: 1) O3, 2) Ph3P / 1) CH2Cl2, MeOH, -10 deg C, 40 min, 2) room temperature, 3 h
参考文献
Choudhry, Satish C.; Belica, Peter S.; Coffen, David L.; Focella, Antonino; Maehr, Hubert; et al. Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1496 - 1500
反应条件
Multi-step reaction with 2 steps 1: 54.9 g / SeO2, 4-methylmorpholine N-oxide / methanol / 5.5 h / Heating2: imidazole / CH2Cl2 / 6 h / Ambient temperature
参考文献
Choudhry, Satish C.; Belica, Peter S.; Coffen, David L.; Focella, Antonino; Maehr, Hubert; et al. Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1496 - 1500
反应条件
Multi-step reaction with 5 steps 1: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating2: imidazole / dimethylformamide / 1.5 h / 20 °C3: liq. SO2 / diethyl ether / 0.5 h / Heating4: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C5: 5 percent / NaHCO3 / ethanol / 1.5 h / Heating
参考文献
Calverley Tetrahedron, 1987 , vol. 43, # 20 p. 4609-4619
