N-甲氧基-N-甲基庚酰胺合成路线 （共 11 条）
参考文献
Hayes, Christopher J.; Bradley, Daniel M.; Thomson, Nicholas M.
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2661 - 2665
反应条件
1: hexane carboxylic acid With N-ethyl-N,N-diisopropylamine; [bis(2-methoxyethyl)amino]-sulfur trifluoride in N,N-dimethyl-formamide T=0°C; 0.25 h; 2: N,O-dimethyl-hydroxylamine in N,N-dimethyl-formamide T=0 - 20°C; 3 h; Further stages.;
参考文献
Tunoori, Ashok Rao; White, Jonathan M.; Georg, Gunda I.
Organic Letters, 2000 , vol. 2, # 25 p. 4091 - 4093
反应条件
pyridine in dichloromethane
参考文献
Lee, Kee-Young; Oh, Chang-Young; Kim, Yong-Hyun; Joo, Jae-Eun; Ham, Won-Hun
Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9361 - 9363
反应条件
1: N,N-diisopropylethylamine; [bis(2-methoxyethyl)amino]sulfur trifluoride / CH2Cl2 / 0 °C 2: CH2Cl2 / 3.25 h / 0 - 20 °C View Scheme
参考文献
Alonso, Emma; Ramon, Diego J.; Yus, Miguel
Anales de Quimica, 1998 , vol. 94, # 1 p. 56 - 61
反应条件
in dichloromethane T=0 - 20°C; 3.25 h;
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
参考文献
Guanti, Giuseppe; Banfi, Luca; Narisano, Enrica
Tetrahedron Letters, 1986 , vol. 27, # 30 p. 3547 - 3550
反应条件
1.1: 93 percent / tetrahydrofuran 2.1: 90 percent / PTSA / benzene 3.1: methanol / 92 °C 3.2: 92 percent / NaBH4 4.1: 87 percent / PPH3; Imidazol / CH2Cl2 5.1: 71 percent / t-BuLi; ZnCl2 / tetrahydrofuran / 20 °C 6.1: 78 percent / HCl / tetrahydrofuran 7.1: 79 percent / NaOH / H2O / Heating View Scheme
参考文献
Lee, Kee-Young; Oh, Chang-Young; Kim, Yong-Hyun; Joo, Jae-Eun; Ham, Won-Hun
Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9361 - 9363
反应条件
N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide T=100°C;
参考文献
Cutulic, Sylvain P. Y.; Murphy, John A.; Farwaha, Hardeep; Zhou, Sheng-Ze; Chrystal, Ewan
Synlett, 2008 , # 14 p. 2132 - 2136
反应条件
water
1) ether, RT; Yield given. Multistep reaction;
参考文献
Bergman; Nilsson; Wickberg
Tetrahedron Letters, 1990 , vol. 31, # 19 p. 2783 - 2786
反应条件
1.1: 93 percent / tetrahydrofuran
2.1: 90 percent / PTSA / benzene
3.1: methanol / 92 °C
3.2: 92 percent / NaBH4
4.1: 87 percent / PPH3; Imidazol / CH2Cl2
View Scheme
参考文献
Lee, Kee-Young; Oh, Chang-Young; Kim, Yong-Hyun; Joo, Jae-Eun; Ham, Won-Hun
Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9361 - 9363
