DL-4-氯-3-羟基丁酸乙酯合成路线 （共 23 条）
反应条件
FAS; mercury(II) dithiocyanate in ethanol T=30°C; pH=7.5; Enzymatic reaction; Kinetics;
参考文献
Schallmey, Marcus; Floor, Robert J.; Hauer, Bernhard; Breuer, Michael; Jekel, Peter A.; Wijma, Hein J.; Dijkstra, Bauke W.; Janssen, Dick B.
ChemBioChem, 2013 , vol. 14, # 7 p. 870 - 881
反应条件
1: in water T=80 - 90°C; 3 h; 2: With hydrogenchloride; water T=80 - 90°C; 2 h;
参考文献
ENZYTECH, LTD.
Patent: WO2007/139238 A1, 2007 ;
Location in patent: Page/Page column 9-10 ;
反应条件
hydrogenchloride 1.) ethanol, reflux 6 h; 2.) reflux 3 h.; Yield given. Multistep reaction;
参考文献
Pellegata, R.; Dosi, I.; Villa, M.; Lesma, G.; Palmisano, G.
Tetrahedron, 1985 , vol. 41, # 23 p. 5607 - 5614
反应条件
ammonium hydroxide T=80°C; 3 h;
参考文献
Pellegata, R.; Dosi, I.; Villa, M.; Lesma, G.; Palmisano, G.
Tetrahedron, 1985 , vol. 41, # 23 p. 5607 - 5614
反应条件
FAS; mercury(II) dithiocyanate in ethanol T=30°C; pH=7.5; Enzymatic reaction; Kinetics;
参考文献
Schallmey, Marcus; Floor, Robert J.; Hauer, Bernhard; Breuer, Michael; Jekel, Peter A.; Wijma, Hein J.; Dijkstra, Bauke W.; Janssen, Dick B.
ChemBioChem, 2013 , vol. 14, # 7 p. 870 - 881
反应条件
1: With sodium tetrahydroborate in methanol; toluene T=20°C; 12 h; 2: With hydrogenchloride; water in methanol; toluene T=10°C; Product distribution / selectivity;
参考文献
RSTECH CORPORATION
Patent: WO2008/93955 A1, 2008 ;
Location in patent: Paragraph 71-72 ;
反应条件
acetic acid in water T=105 - 110°C; 0.02125 h;
参考文献
PHOENIX CHEMICALS LIMITED
Patent: WO2003/97581 A1, 2003 ;
Location in patent: Page/Page column 12-13 ;
反应条件
sulfuric acid; sodium hydroxide in water T=40°C; pH=7.3; Enzymatic reaction;
参考文献
Ma, Steven K.; Gruber, John; Davis, Chris; Newman, Lisa; Gray, David; Wang, Alica; Grate, John; Huisman, Gjalt W.; Sheldon, Roger A.
Green Chemistry, 2010 , vol. 12, # 1 p. 81 - 86
反应条件
1: hydrogen cyanide With halohydrin dehalogenase in water T=40°C; pH=7; 0.5 h; 2: (S)-4-chloro-3-hydroxybutyric acid ethyl ester in water pH=7; 21 h; Product distribution / selectivity;
参考文献
CODEXIS, INC.
Patent: WO2005/18579 A2, 2005 ;
Location in patent: Page/Page column 54 ;
反应条件
in water T=55°C; pH=8.5 - 9; 3 h; Product distribution / selectivity;
参考文献
CODEXIS, INC.
Patent: WO2005/18579 A2, 2005 ;
Location in patent: Page/Page column 57-58 ;
