2-甲基-3-氧代-3-苯基丙酸乙酯合成路线 （共 76 条）
反应条件
(i) NH2OH*HCl, aq. NaOH, (ii) aq. HCl; Multistep reaction;
参考文献
Jacquier,R. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 2685 - 2690
反应条件
1: 1.) NaH, 60percent in oil / 1.) DMSO, until homogeneous; 2.) DMSO, overnight 2: (Bu3Sn)2 / acetonitrile; benzene / 36 h / Irradiation View Scheme
参考文献
Best, Wayne M.; Cook, Anthony P. F.; Russell, James J.; Widdowson, David A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1139 - 1144
反应条件
mixture of gaseous nitrogen oxides
参考文献
Schmidt,J.; Dieterle
Justus Liebigs Annalen der Chemie, 1910 , vol. 377, p. 53 Anm.
反应条件
in acetonitrile-D3
T=20 - 28°C;
参考文献
Katrizky, Alan R.; Barczynski, Piotr; Ostercamp, Daryl L.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 969 - 976
反应条件
in acetonitrile-D3
T=20 - 28°C;
参考文献
Katrizky, Alan R.; Barczynski, Piotr; Ostercamp, Daryl L.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 969 - 976
反应条件
in acetonitrile-D3
T=20 - 28°C;
参考文献
Katrizky, Alan R.; Barczynski, Piotr; Ostercamp, Daryl L.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 969 - 976
反应条件
in acetonitrile-D3
T=20 - 28°C;
参考文献
Katrizky, Alan R.; Barczynski, Piotr; Ostercamp, Daryl L.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 969 - 976
反应条件
1: ethanol
2: POCl3
View Scheme
参考文献
Burroughs Wellcome and Co.
Patent: US2688019 , 1951 ;
反应条件
1.1: 80 percent / H2SO4; CF3COOH / 4 h / 20 °C
2.1: NaH / dimethylformamide / 0.33 h / 0 °C
2.2: 83 percent / NaH / dimethylformamide / 5 h / 0 - 20 °C
3.1: 40 percent / N-bromosuccinimde; benzoyl peroxide / CCl4 / Heating
View Scheme
参考文献
Leonetti, Francesco; Favia, Angelo; Rao, Angela; Aliano, Rosaria; Paluszcak, Anja; Hartmann, Rolf W.; Carotti, Angelo
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6792 - 6803
反应条件
sulfuric acid
T=100°C;
参考文献
Simonis; Wojack
Chemische Berichte, 1937 , vol. 70, p. 1837,1846
