1: ethyl acetoacetate With sodium hydride in tetrahydrofuran
T=20°C; 0.666667 h;
2: 1-benzotriazol-1-yl-hexan-1-one in tetrahydrofuran
T=20°C; 14 h;
3: With ammonium hydroxide; ammonium chloride in tetrahydrofuran; water
1 h; Heating;
参考文献
Katritzky, Alan R.; Wang, Zuoquan; Wang, Mingyi; Wilkerson, Chavon R.; Hall, C. Dennis; Akhmedov, Novruz G.
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6617 - 6622
1: ethyl acetoacetate With sodium hydride in tetrahydrofuran
T=0°C; 0.333333 h;
2: With tert.-butyl lithium in tetrahydrofuran; pentane
T=0°C; 30 h;
3: 1-iodo-butane in tetrahydrofuran; pentane
Further stages.;
参考文献
Lager, Erik; Nilsson, Jakob; stergaard Nielsen, Elsebet; Nielsen, Mogens; Liljefors, Tommy; Sterner, Olov
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6936 - 6948
Jackman et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 2884
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Soloway; La Forge
Journal of the American Chemical Society, 1947 , vol. 69, p. 2678
1: pyridine / CH2Cl2 / Ambient temperature
2: 35.9 g / 5 h / Heating
View Scheme
参考文献
Anderson, John R.; Edwards, Raymond L.; Whalley, Anthony J.S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1481 - 1486
Crombie, Leslie; Jones, Raymond C. F.; Palmer, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 317 - 332
