2,3-二氢-2,2-二甲基茚-1-酮合成路线 （共 46 条）
反应条件
Lawesson's reagent in toluene Heating; Yield given;
参考文献
Yeung, Lam Lung; Yip, Yu Chi; Luh, Tien-Yau
Journal of Organic Chemistry, 1990 , vol. 55, # 6 p. 1874 - 1881
反应条件
1: 1,3-dihydro-1-oxo-2H-indene With sodium hydride in ethylene glycol dimethyl ether
T=20°C; 0.166667 h;
2: methyl iodide in ethylene glycol dimethyl ether
T=20°C; 1 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1688138 A1, 2006 ;
Location in patent: Page/Page column 80 ;
EP 1688138 A1
反应条件
tetraazafulvalene in N,N-dimethyl-formamide
T=20°C; 2 h;
参考文献
Murphy, John A.; Zhou, Sheng-Ze; Thomson, Douglas W.; Schoenebeck, Franziska; Mahesh, Mohan; Park, Stuart R.; Tuttle, Tell; Berlouis, Leonard E. A.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 27 p. 5178 - 5183
反应条件
IAd*HBF4; [Pd(η3-2-Me-C3H4)(μ-Cl)]2; bisallyl ether; caesium carbonate in 1,4-dioxane
T=110°C; 14 h; Inert atmosphere;
参考文献
Flores-Gaspar, Areli; Gutierrez-Bonet, Alvaro; Martin, Ruben
Organic Letters, 2012 , vol. 14, # 20 p. 5234 - 5237,4
Title/Abstract Full Text Show Details
Flores-Gaspar, Areli; Gutierrez-Bonet, Alvaro; Martin, Ruben
Organic Letters, 2012 , vol. 14, # 20 p. 5234 - 5237
反应条件
potassium tert-butylate
参考文献
Sternerup,H.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1974 , vol. 28, p. 969 - 980
反应条件
palladium diacetate; caesium carbonate; PCy3∙HBF4; 2,2,2-trimethylacetic acid in 1,3,5-trimethyl-benzene
T=140°C; 16 h; Inert atmosphere;
参考文献
Rousseaux, Sophie; Davi, Michael; Sofack-Kreutzer, Julien; Pierre, Cathleen; Kefalidis, Christos E.; Clot, Eric; Fagnou, Keith; Baudoin, Olivier
Journal of the American Chemical Society, 2010 , vol. 132, # 31 p. 10706 - 10716
反应条件
palladium diacetate; caesium carbonate; PCy3∙HBF4; 2,2,2-trimethylacetic acid in 1,3,5-trimethyl-benzene
T=140°C; 16 h; Inert atmosphere;
参考文献
Rousseaux, Sophie; Davi, Michael; Sofack-Kreutzer, Julien; Pierre, Cathleen; Kefalidis, Christos E.; Clot, Eric; Fagnou, Keith; Baudoin, Olivier
Journal of the American Chemical Society, 2010 , vol. 132, # 31 p. 10706 - 10716
反应条件
bis(1,5-cyclooctadiene)nickel (0); It-Bu2 in 1,3,5-trimethyl-benzene
T=130°C; 6 h; Inert atmosphere;
参考文献
Hoshimoto, Yoichi; Hayashi, Yukari; Suzuki, Haruka; Ohashi, Masato; Ogoshi, Sensuke
Angewandte Chemie - International Edition, 2012 , vol. 51, # 43 p. 10812 - 10815
Angew. Chem., 2012 , vol. 124, # 43 p. 10970 - 10973,4
参考文献
Warrick,P.; Saunders,W.H.
Journal of the American Chemical Society, 1962 , vol. 84, p. 4095 - 4100
反应条件
1.1: n-BuLi; i-Pr2NH / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: 48 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 3 percent / PPh3; Et3N / Pd(OAc)2 / dimethylformamide; H2O / 15 h / 130 °C
View Scheme
参考文献
Pletnev, Alexandre A.; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9428 - 9438
