2,3-二氢-2,2-二甲基茚-1-酮合成路线 （共 46 条）
反应条件
1.1: n-BuLi; i-Pr2NH / hexane; tetrahydrofuran / 1 h / -78 - 20 °C
1.2: 94 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 88 percent Spectr. / PPh3; Et3N / Pd(OAc)2 / dimethylformamide; H2O / 12 h / 130 °C
View Scheme
参考文献
Pletnev, Alexandre A.; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9428 - 9438
反应条件
1.1: BH3*SMe2 / tetrahydrofuran / 0 - 20 °C
2.1: CBr4; PPH3 / CH2Cl2 / 0 °C
3.1: n-BuLi; i-Pr2NH / hexane; tetrahydrofuran / 1 h / -78 °C
3.2: 48 percent / tetrahydrofuran; hexane / -78 - 20 °C
4.1: 3 percent / PPh3; Et3N / Pd(OAc)2 / dimethylformamide; H2O / 15 h / 130 °C
View Scheme
参考文献
Pletnev, Alexandre A.; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9428 - 9438
反应条件
1.1: CBr4; PPH3 / CH2Cl2 / 0 °C
2.1: n-BuLi; i-Pr2NH / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 48 percent / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 3 percent / PPh3; Et3N / Pd(OAc)2 / dimethylformamide; H2O / 15 h / 130 °C
View Scheme
参考文献
Pletnev, Alexandre A.; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9428 - 9438
反应条件
aluminium trichloride in benzene
T=21 - 22°C;
参考文献
Bruson,H.A.; Plant,H.L.
Journal of Organic Chemistry, 1967 , vol. 32, p. 3356 - 3362
反应条件
in tetrahydrofuran; pentane
T=-78°C; 0.25 h;
参考文献
Beak, Peter; Park, Yong Sun; Reif, Lee A.; Liu, Chao
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7410 - 7413
反应条件
aluminium trichloride in benzene
参考文献
Bruson,H.A.; Plant,H.L.
Journal of Organic Chemistry, 1967 , vol. 32, p. 3356 - 3362
反应条件
aluminium trichloride
T=24 - 26°C;
参考文献
Bruson,H.A.; Plant,H.L.
Journal of Organic Chemistry, 1967 , vol. 32, p. 3356 - 3362
反应条件
aluminium trichloride
T=24 - 27°C;
参考文献
Bruson,H.A.; Plant,H.L.
Journal of Organic Chemistry, 1967 , vol. 32, p. 3356 - 3362
反应条件
aluminium trichloride
T=24 - 27°C;
参考文献
Bruson,H.A.; Plant,H.L.
Journal of Organic Chemistry, 1967 , vol. 32, p. 3356 - 3362
反应条件
aluminium trichloride
T=24 - 27°C;
参考文献
Bruson,H.A.; Plant,H.L.
Journal of Organic Chemistry, 1967 , vol. 32, p. 3356 - 3362
