lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '109781', constants.ctx, '0')">2-methyl-1H-indole</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=0&deg;C;&nbsp;0.5&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '956569', constants.ctx, '0')">cyanomethyl bromide</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=0 - 20&deg;C;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: N-bromosuccinimide (NBS), peroxyde de benzoyle / CCl₄ <br />2: 96 percent / diethyl ether / 1.) 2 h, RT; 2.) 1 h, reflux<br />3: 83 percent / 48percent HBr, Zn / ethanol / 2 h / Heating<br />4: 93 percent / pyridine / CH₂Cl₂ / 1 h / Heating<br />5: 72 percent / tertioamylate de sodium / CH₂Cl₂; toluene / 2 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 96 percent / diethyl ether / 1.) 2 h, RT; 2.) 1 h, reflux<br />2: 83 percent / 48percent HBr, Zn / ethanol / 2 h / Heating<br />3: 93 percent / pyridine / CH₂Cl₂ / 1 h / Heating<br />4: 72 percent / tertioamylate de sodium / CH₂Cl₂; toluene / 2 h / Ambient temperature<br /> <br /> &nbsp;