2-氨基-n-丁基苯甲酰胺合成路线 （共 13 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 16 h;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2008/94909 A2, 2008 ;
Location in patent: Page/Page column 109 ;
WO 2008/094909 A2
反应条件
4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide 1 h; Ambient temperature;
参考文献
Venuti, Michael C.
Synthesis, 1982 , # 4 p. 266 - 268
反应条件
1: diluted hydrochloric acid View Scheme
参考文献
Mahiwal, Kuldeep; Kumar, Pradeep; Narasimhan, Balasubramanian
Medicinal Chemistry Research, 2012 , vol. 21, # 3 p. 293 - 307
反应条件
in diethyl ether T=0 - 10°C; 0.5 h;
参考文献
Mahiwal, Kuldeep; Kumar, Pradeep; Narasimhan, Balasubramanian
Medicinal Chemistry Research, 2012 , vol. 21, # 3 p. 293 - 307
反应条件
1: aq. NaOH solution 2: platinum; ethanol / Hydrogenation View Scheme
参考文献
Leonard; Ruyle
Journal of Organic Chemistry, 1948 , vol. 13, p. 903,908
反应条件
potassium alum in ethanol 4 h; Reflux;
参考文献
Mohammadi, Ali A.; Dabiri; Qaraat
Tetrahedron, 2009 , vol. 65, # 18 p. 3804 - 3808
参考文献
Clark; Wagner
Journal of Organic Chemistry, 1944 , vol. 9, p. 55,61, 63
反应条件
potassium hydroxide in ethanol; water 8 h; Reflux;
参考文献
Elansary, Afaf K.; Kadry, Hanan H.; Ahmed, Eman M.; Sonousi, Amr Sayed Motawi
Medicinal Chemistry Research, 2012 , vol. 21, # 11 p. 3327 - 3335
反应条件
iodine T=80°C; 0.5 h; Ionic liquid;
参考文献
Wang, Shu-Liang; Yang, Ke; Yao, Chang-Sheng; Wang, Xiang-Shan.
Synthetic Communications, 2012 , vol. 42, # 3 p. 341 - 349
参考文献
Farzipour, Soghra; Saeedi, Mina; Mahdavi, Mohammad; Yavari, Hossein; Mirzahekmati, Mohammadreza; Ghaemi, Nasser; Foroumadi, Alireza; Shafiee, Abbas
Synthetic Communications, 2014 , vol. 44, # 4 p. 481 - 487
