1-(6-氯-9H-嘌呤-9-基)-1-脱氧-2,3-O-异亚丙基-beta-D-呋喃核糖酰氯合成路线 （共 5 条）
反应条件
1: 83 percent / 2,2,6,6-tetramethyl-1-piperidinyloxy free radical; iodosobenzene diacetate / acetonitrile; H2O / 4 h / 20 °C 2: SOCl2; DMF / CHCl3 / 5 h / Heating View Scheme
参考文献
Olsson; Kusachi; Thompson; Ukena; Padgett; Daly
Journal of medicinal chemistry, 1986 , vol. 29, # 9 p. 1683 - 1689
反应条件
1: 60 percent / tosic acid monohydrate / acetone / 18 h / 20 °C 2: 83 percent / 2,2,6,6-tetramethyl-1-piperidinyloxy free radical; iodosobenzene diacetate / acetonitrile; H2O / 4 h / 20 °C 3: SOCl2; DMF / CHCl3 / 5 h / Heating View Scheme
参考文献
Middleton, Richard J.; Briddon, Stephen J.; Cordeaux, Yolande; Yates, Andrew S.; Dale, Clare L.; George, Michael W.; Baker, Julian G.; Hill, Stephen J.; Kellam, Barrie
Journal of Medicinal Chemistry, 2007 , vol. 50, # 4 p. 782 - 793
反应条件
in chloroform T=10°C; 0.333333 h;
参考文献
Gallo-Rodriguez, Carola; Ji, Xiao-duo; Melman, Neli; Siegman, Barry D.; Sanders, Lawrence H.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 636 - 646
反应条件
1: NH3 / CHCl3 / 0.33 h / 10 °C 2: NH3, (C2H5)3N / ethanol / 48 h / Heating 3: 1 N aq. HCl / 1 h / 60 °C View Scheme
参考文献
Olsson; Kusachi; Thompson; Ukena; Padgett; Daly
Journal of medicinal chemistry, 1986 , vol. 29, # 9 p. 1683 - 1689
反应条件
1: CHCl3 / 0.25 h / 10 °C 2: Et3N / ethanol / 16 h / 75 °C 3: 1N HCl / 4 h / 60 °C View Scheme
参考文献
Gallo-Rodriguez, Carola; Ji, Xiao-duo; Melman, Neli; Siegman, Barry D.; Sanders, Lawrence H.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 636 - 646
