6-溴-2,2'-联吡啶合成路线 （共 27 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=0 - 20°C; 5 h; Inert atmosphere;
参考文献
Hodogaya Chemical Co., Ltd.; Kyushu University, National University Corporation; ADACHI, Chihaya; YASUDA, Takuma; TOGASHI, Kazunori; NOMURA, Shintaro
Patent: EP2679582 A1, 2014 ;
Location in patent: Paragraph 0106 ;
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in toluene 15.5 h; Reflux; 2: With ammonium hydroxide in water 1.5 h; Cooling with ice;
参考文献
Heuberger, Benjamin D.; Shin, Dongwon; Switzer, Christopher
Organic Letters, 2008 , vol. 10, # 6 p. 1091 - 1094
反应条件
1: 1.) n-butyllithium, 2.) CuBr, O2 / 1.) ether, hexane, -80 deg C, 0.5 h, 2.) a) -85 deg C, 0.5 h, b) -70 deg C, 0.5 h 2: 88 percent / phenyllithium / tetrahydrofuran; diethyl ether / 1 h / -85 - -80 °C / cyclohexane as third solvent View Scheme
参考文献
Synthetic Communications, , vol. 20, # 8 p. 1233 - 1239
反应条件
bromine; triphenylphosphine in acetonitrile T=0°C; 48 h; Reflux;
参考文献
Boettger, Matthias; Wiegmann, Bjoern; Schaumburg, Steffen; Jones, Peter G.; Kowalsky, Wolfgang; Johannes, Hans-Hermann
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1037 - 1047
反应条件
1: With methyl iodide in acetonitrile T=45°C; 2: With potassium hexacyanoferrate(III) in sodium hydroxide T=5°C; 3: With bromine; triphenylphosphine in acetonitrile T=0°C;
参考文献
Tetrahedron Letters, , vol. 47, # 39 p. 6941 - 6943
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; Negishi reaction; 24 h;
参考文献
Synlett, , # 6 p. 852 - 854
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran T=-78°C; 2: With trimethylstannyl chloride in tetrahydrofuran Reflux; 3: 2,6-Dibromopyridine With tetrakis(triphenylphosphine) palladium(0) in toluene Reflux;
参考文献
Munoz-Rodriguez, Rebeca; Bunuel, Elena; Gareth Williams; Cardenas, Diego J.
Chemical Communications, 2012 , vol. 48, # 48 p. 5980 - 5982
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; copper(l) iodide in N,N-dimethyl-formamide T=100°C; Suzuki-Miyaura cross-coupling reaction; 6 h;
参考文献
Jones, Nicholas A.; Antoon, James W.; Bowie Jr., Alfred L.; Borak, J. Brian; Stevens, Erland P.
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 2 p. 363 - 367
反应条件
phosphorus tribromide T=165°C; 5 h;
参考文献
Hanan, Garry S.; Schubert, Ulrich S.; Volkmer, Dirk; Riviere, Emmanuel; Lehn, Jean-Marie; Kyritsakas, Nathalie; Fischer, Jean
Canadian Journal of Chemistry, 1997 , vol. 75, # 2 p. 169 - 182
反应条件
phenyllithium in tetrahydrofuran; diethyl ether; cyclohexane T=-85 - -80°C; 1 h;
参考文献
Garber, Ty; Rillema, D. Paul
Synthetic Communications, 1990 , vol. 20, # 8 p. 1233 - 1239
