2-疏基-6-苯基-4-三氟甲基烟腈合成路线 （共 8 条）
反应条件
triethylamine in ethanol T=20°C; 24 h;
参考文献
Rodinovskaya, L. A.; Sharanin, Yu. A.; Litvinov, V. P.; Shestopalov, A. M.; Promonenkov, V. K.; et al.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2230 - 2235
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2439 - 2444
反应条件
in ethanol T=25 - 30°C; 24 h;
参考文献
Rodinovskaya, L. A.; Sharanin, Yu. A.; Litvinov, V. P.; Shestopalov, A. M.; Promonenkov, V. K.; et al.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2230 - 2235
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2439 - 2444
反应条件
1: 78 percent / POCl3, DMF / 8 h / 130 °C 2: 63 percent / Na2S*9H2O / dimethylformamide / 10 h / 20 °C View Scheme
参考文献
Guttsait, A. V.; Belyakov, S. V.; Mishnev, A. F.; Bleidelis, Ya. Ya.; Gudrinietse, E. Yu.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 9 p. 986 - 989
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 9 p. 1233 - 1237
反应条件
1: sodium methylate / methanol; tetrahydrofuran / 0 - 20 °C 2: 1,4-diaza-bicyclo[2.2.2]octane / ethanol / 20 °C / |Reflux View Scheme
参考文献
Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1581 - 1588
反应条件
potassium hydroxide in N,N-dimethyl-formamide 0.5 h;
参考文献
Rodinovskaya, L. A.; Sharanin, Yu. A.; Litvinov, V. P.; Shestopalov, A. M.; Promonenkov, V. K.; et al.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2230 - 2235
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2439 - 2444
反应条件
1: 47 percent / 10percent aq. KOH / dimethylformamide 2: 87 percent / 10percent aq. KOH / dimethylformamide / 0.5 h / 20 °C View Scheme
参考文献
Rodinovskaya, L. A.; Sharanin, Yu. A.; Litvinov, V. P.; Shestopalov, A. M.; Promonenkov, V. K.; et al.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2230 - 2235
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2439 - 2444
反应条件
1: 92 percent / 10percent aq. KOH / dimethylformamide / 0.33 h / 20 °C 2: 59 percent / sodium ethanolate / ethanol / 2 h / Heating View Scheme
参考文献
Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1581 - 1588
反应条件
1: 75 percent / 10percent aq. NaOH, 10percent I2 / H2O; ethanol 2: 57 percent / CrO3 / H2O; acetic anhydride / 2.5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 21, # 11 p. 2230 - 2235
Zhurnal Organicheskoi Khimii, , vol. 21, # 11 p. 2439 - 2444
