3-氨基-6-苯基-4-(三氟甲基)噻吩并[2,3-b]吡啶-2-羧酸合成路线 （共 4 条）
反应条件
1: 84 percent / triethylamine / ethanol / 24 h / 20 °C 2: 92 percent / 10percent aq. KOH / dimethylformamide / 0.33 h / 20 °C 3: 59 percent / sodium ethanolate / ethanol / 2 h / Heating View Scheme
参考文献
Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1581 - 1588
反应条件
1: 92 percent / 10percent aq. KOH / dimethylformamide / 0.33 h / 20 °C 2: 59 percent / sodium ethanolate / ethanol / 2 h / Heating View Scheme
参考文献
Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1581 - 1588
反应条件
1: 88 percent / ethanol / 24 h / 25 - 30 °C 2: 92 percent / 10percent aq. KOH / dimethylformamide / 0.33 h / 20 °C 3: 59 percent / sodium ethanolate / ethanol / 2 h / Heating View Scheme
参考文献
Rodinovskaya, L. A.; Sharanin, Yu. A.; Litvinov, V. P.; Shestopalov, A. M.; Promonenkov, V. K.; et al.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 11 p. 2230 - 2235
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 11 p. 2439 - 2444
反应条件
1: sodium methylate / methanol; tetrahydrofuran / 0 - 20 °C 2: 1,4-diaza-bicyclo[2.2.2]octane / ethanol / 20 °C / |Reflux 3: potassium hydroxide / N,N-dimethyl-formamide; water / 20 °C 4: lithium hydroxide hydrate / methanol; tetrahydrofuran; water / 20 °C View Scheme
参考文献
Wang, Ning-Yu; Zuo, Wei-Qiong; Xu, Ying; Gao, Chao; Zeng, Xiu-Xiu; Zhang, Li-Dan; You, Xin-Yu; Peng, Cui-Ting; Shen, Yang; Yang, Sheng-Yong; Wei, Yu-Quan; Yu, Luo-Ting
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1581 - 1588
