3-溴-4-三氟甲氧基苯甲醚合成路线 (共 2 条)
反应条件
potassium carbonate in acetone 10 h;
参考文献
MYRIAD GENETICS, INC.
Patent: WO2009/65035 A1, 2009 ;
Location in patent: Page/Page column 67 ;
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes T=-70°C; 1 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexanes T=-70°C; 2 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexanes pH=~ 5;
参考文献
PFIZER LIMITED
Patent: WO2008/135826 A2, 2008 ;
Location in patent: Page/Page column 173; 174 ;
WO 2008/135826 A2