1: 1.) NaH / 1.) THF, from -5 deg C to RT, 2.) THF, RT, 12 h
2: 61 percent / tetrahydrofuran / 16 h / Heating
3: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, 16 h
View Scheme
参考文献
Manley, Paul W.; Allanson, Nigel M.; Booth, Robert F. G.; Buckle, Philip E.; Kuzniar, Edward J.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1588 - 1595
