反应条件
Multi-step reaction with 3 steps 1: tetrabutylammomium bromide; oxygen; potassium hydroxide / N,N,N',N'-tetramethyl-urea / 20 °C2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate / toluene / 24 h / 90 °C / Inert atmosphere3: potassium phosphate; chloro(di-2-norbornylphosphino)(2-dimethylamino-1,1'-biphenyl-2-yl)palladium / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere
参考文献
Shetty, Rupa S.; Lee, Younghee; Liu, Bin; Husain, Arifa; Joseph, Rhoda W.; Lu, Yixin; Nelson, David; Mihelcic, John; Chao, Wenchun; Moffett, Kristofer K.; Schumacher, Andreas; Flubacher, Dietmar; Stojanovic, Aleksandar; Bukhtiyarova, Marina; Williams, Ken; Lee, Kyoung-Jin; Ochman, Alexander R.; Saporito, Michael S.; Moore, William R.; Flynn, Gary A.; Dorsey, Bruce D.; Springman, Eric B.; Fujimoto, Ted; Kelly, Martha J. Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 179 - 200