反应条件
1: Amano lipase PS-C1 / dichloromethane / 19 h / 20 °C / Inert atmosphere; Resolution of racemate; Large scale reaction; Enzymatic reaction 2: triethylamine / tert-butyl methyl ether / -10 - 25 °C / Inert atmosphere; Large scale reaction 3: tetrabutylammomium bromide; sodium bromide / water / Inert atmosphere; Heating; Large scale reaction 4: potassium tert-butylate / Inert atmosphere View Scheme
参考文献
Murtagh, Lorraine; Dunne, Catherine; Gabellone, Gino; Panesar, Niamh J.; Field, Stuart; Reeder, Lisa M.; Saenz, James; Smith, George P.; Kissick, Kyle; Martinez, Carlos; Van Alsten, John G.; Evans, Margaret C.; Franklin, Lloyd C.; Nanninga, Thomas; Wong, John
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1315 - 1327