1: acetoacetic acid methyl ester With sodium hydride in toluene; mineral oil
T=20°C; 0.166667 h;
2: 2-fluoro-benzoyl chloride in toluene; mineral oil
Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BATT, Douglas, G.
Patent: WO2010/9069 A1, 2010 ;
Location in patent: Page/Page column 39 ;
WO 2010/009069 A1
1: acetoacetic acid methyl ester With lithium diisopropyl amide in tetrahydrofuran; hexane
T=0°C; 0.75 h;
2: 1-bromo-2-chloro-ethane in tetrahydrofuran; hexane
T=-78 - 68°C; 28 h; Further stages. Title compound not separated from byproducts.;
参考文献
Langer; Holtz; Karime; Saleh
Journal of Organic Chemistry, 2001 , vol. 66, # 18 p. 6057 - 6063