1,3-丙酮二羧酸二乙酯合成路线 （共 169 条）
反应条件
1: With morpholine in N,N-dimethyl-formamide T=25 - 35°C; 2: With sulfur in N,N-dimethyl-formamide T=25 - 55°C; 3: With water in N,N-dimethyl-formamide T=25 - 55°C;
参考文献
ACTAVIS GROUP PTC EHF; SEBASTIAN, Sonny; PERI, Seetha, Rama, Sarma; JAGADALE, Prashant; PRADHAN, Nitin, Sharadchandra
Patent: WO2011/124992 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
1: concentrated aqueous HCl / anschliessend Erwaermen mit Acetessigsaeure-benzylester, Zink-Pulver, Essigsaeure und Ammoniumacetat 2: Raney nickel; ethanol / 100 °C / 73550.8 Torr / Hydrogenation 3: glycerol / 230 °C 4: aqueous NaOH 5: resorcinol 6: toluene 7: ethanol View Scheme
参考文献
MacDonald
Journal of the Chemical Society, 1952 , p. 4176,4182
反应条件
1: Et2NH 2: H2SO4 View Scheme
参考文献
Plante, Jeffrey P.; Jones, Paul D.; Powell, Douglas R.; Glass, Timothy E.
Chemical Communications, 2003 , # 3 p. 336 - 337
反应条件
1: ethanol / anschliessendes Behandeln mit amalgamiertem Aluminium und wenig H2O 2: Ba(OH)2 View Scheme
参考文献
Gootjes; Nauta
Recueil des Travaux Chimiques des Pays-Bas, 1953 , vol. 72, p. 721,72
反应条件
1: diethyl acetone-1,3-dicarboxylate With lithium diisopropyl amide in tetrahydrofuran; hexane T=-18°C; 0.166667 h; 2: iso-butyl iodide in tetrahydrofuran; hexane T=-18 - 20°C; 4.5 h; Further stages.;
参考文献
Kambourakis, Spiros; Rozzell, J. David
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 6-7 p. 699 - 705
反应条件
magnesium diethoxide 1.) EtOH, reflux, 90 min, 2.) EtOH, reflux, 16 h; Yield given. Multistep reaction;
参考文献
Beszant; Bird; Gaster; Harper; Hughes; Karran; Markwell; Miles-Williams; Smith
Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 4030 - 4039
反应条件
sulfuric acid
24 h; Ambient temperature;
参考文献
Seward, Eileen; Diederich, Francois
Tetrahedron Letters, 1987 , vol. 28, # 43 p. 5111 - 5114
反应条件
selenium(IV) oxide
T=100 - 110°C;
参考文献
Astin; Moulds; Riley
Journal of the Chemical Society, 1935 , p. 901,903
参考文献
Astin; Moulds; Riley
Journal of the Chemical Society, 1935 , p. 901,903
参考文献
Unterhalt; Pindur
Archiv der Pharmazie, 1976 , vol. 309, # 10 p. 781 - 786
