1,3-丙酮二羧酸二乙酯合成路线 （共 169 条）
反应条件
1: Raney nickel; ethanol / 100 °C / 102971 Torr / Hydrogenation
View Scheme
参考文献
Jewstignejewa et al.
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 1467
Chem.Abstr., 1953 , vol. 47, p. 5949
反应条件
1.1: acetic anhydride / 1.5 h / 120 °C
1.2: 0 °C / Cooling
1.3: pH < 5
2.1: trichlorophosphate / 3 h / 110 °C
3.1: acetonitrile; water / 3.5 h / 0 - 20 °C
View Scheme
参考文献
FLYNN, Daniel L.; KAUFMAN, Michael D.
Patent: WO2013/184119 A1, 2013 ;
反应条件
1.1: acetic anhydride / 1.5 h / 120 °C
1.2: 0 °C / Cooling
1.3: pH < 5
2.1: trichlorophosphate / 3 h / 110 °C
3.1: acetonitrile; water / 3.5 h / 0 - 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C
4.2: 20 °C
View Scheme
参考文献
FLYNN, Daniel L.; KAUFMAN, Michael D.
Patent: WO2013/184119 A1, 2013 ;
反应条件
sodium ethanolate in ethanol
Ambient temperature; Title compound not separated from byproducts;
参考文献
Arslan, Tuncer; Benner, Steven A.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2260 - 2264
参考文献
Jones,W.M. et al.
Journal of the American Chemical Society, 1977 , vol. 99, p. 6379 - 6391
反应条件
piperidine; acetic acid; benzene
参考文献
Tarbell; Wargotz
Journal of the American Chemical Society, 1954 , vol. 76, p. 5761,5764
参考文献
Thiele; Schneider
Justus Liebigs Annalen der Chemie, 1909 , vol. 369, p. 293
反应条件
iodine; magnesium in ethanol
20 h; Heating;
参考文献
Naoshima, Yoshinobu; Ike, Hisashi; Ogawa, Tomiaki; Nakayama, Toru; Kondo, Hirokiyo
Agricultural and Biological Chemistry, 1984 , vol. 48, # 8 p. 2151 - 2154
参考文献
Fries; Volk
Justus Liebigs Annalen der Chemie, 1911 , vol. 379, p. 105
反应条件
hydrogenchloride
anschliessend Erwaermen mit Acetessigsaeure-benzylester, Zink-Pulver, Essigsaeure und Ammoniumacetat;
参考文献
MacDonald
Journal of the Chemical Society, 1952 , p. 4176,4182
