1,3-丙酮二羧酸二乙酯合成路线 （共 169 条）
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; mineral oil
参考文献
Ciba-Geigy Corporation
Patent: US4020098 A1, 1977 ;
反应条件
1: 85 percent / Et3N, anhyd. MgCl2 / benzene / Heating
2: 9.5 percent / diketene / tetrahydrofuran / 20 h / Ambient temperature
View Scheme
参考文献
Yamato, Masatoshi; Kusunoki, Youichiro
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1214 - 1220
参考文献
Mannich
Patent: DE510184 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2435,2436
参考文献
Mannich
Patent: DE510184 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2435,2436
反应条件
1: concentrated aqueous HCl / anschliessend Erwaermen mit Acetessigsaeure-benzylester, Zink-Pulver, Essigsaeure und Ammoniumacetat
2: Raney nickel; ethanol / 100 °C / 73550.8 Torr / Hydrogenation
3: glycerol / 230 °C
View Scheme
参考文献
MacDonald
Journal of the Chemical Society, 1952 , p. 4176,4182
反应条件
1: 86 percent / Et3N / ethanol / 168 h / 20 °C
2: 62 percent / CHCl3 / 24 h / 20 °C
View Scheme
参考文献
Nishiwaki, Nagatoshi; Nishida, Daisei; Ohnishi, Tetsuya; Hidaka, Fumie; Shimizu, Satoru; Tamura, Mina; Hori, Kazushige; Tohda, Yasuo; Ariga, Masahiro
Journal of Organic Chemistry, 2003 , vol. 68, # 22 p. 8650 - 8656
反应条件
1: 85 percent / Et3N, anhyd. MgCl2 / benzene / Heating
2: 0.2 percent / 60 h / Ambient temperature
View Scheme
参考文献
Yamato, Masatoshi; Kusunoki, Youichiro
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1214 - 1220
参考文献
Moyer; McEwen
Journal of the American Chemical Society, 1951 , vol. 73, p. 3075
参考文献
Moyer; McEwen
Journal of the American Chemical Society, 1951 , vol. 73, p. 3075
反应条件
1: PCl5, HCl
4: H2SO4
View Scheme
参考文献
Ainsworth,C.; Chen,F.
Journal of Organic Chemistry, 1970 , vol. 35, # 5 p. 1272 - 1274
