1: 4-fluorobenzaldehyde; diethyl malonate With piperidine in toluene 2.5 h; Reflux; 2: diethyl malonate With sodium ethanolate in ethanol T=0°C; 0.25 h; 3: With hydrogenchloride in ethanol; water 8 h; Reflux;
参考文献
Huang, Xiaojun; Zhu, Jiang; Broadbent, Scott
Tetrahedron Letters, 2010 , vol. 51, # 12 p. 1554 - 1557