1: diethyl malonate With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 1.5 h; Inert atmosphere; 2: bromomethylenecyclohexane in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; 21 h; Inert atmosphere;
参考文献
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN; ZANDA, Matteo; PLATT, Bettina; GREIG, Iain Robert; CALAMAI, Elisa
Patent: WO2013/38153 A1, 2013 ;
Location in patent: Page/Page column 88-89 ;
1: 88 percent / EtONa / ethanol / 3 h / Heating 2: 77 percent / NBS; KO-tBu / 2-methyl-propan-2-ol / 40 h / 35 °C 3: DBU / tetrahydrofuran / 3 h / 0 °C View Scheme
参考文献
Pierik, Antonio J.; Ciceri, Daniele; Broeker, Gerd; Edwards, Christopher H.; McFarlane, William; Winter, Joachim; Buckel, Wolfgang; Golding, Bernard T.
Journal of the American Chemical Society, 2002 , vol. 124, # 47 p. 14039 - 14048