反应条件
1: diethyl malonate With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: 3-bromo-4-chloro-5-nitropyridine in N,N-dimethyl-formamide T=20°C; 1 h; 3: With hydrogenchloride in water; N,N-dimethyl-formamide 16 h; Reflux;
参考文献
Chekler, Eugene L. Piatnitski; Unwalla, Rayomond; Khan, Taukeer A.; Tangirala, Raghuram S.; Johnson, Mark; St. Andre, Michael; Anderson, James T.; Kenney, Thomas; Chiparri, Sue; McNally, Chris; Kilbourne, Edward; Thompson, Catherine; Nagpal, Sunil; Weber, Gregory; Schelling, Scott; Owens, Jane; Morris, Carl A.; Powell, Dennis; Verhoest, Patrick R.; Gilbert, Adam M.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2462 - 2471
