(4-甲氧基-2-硝基苯基)乙腈合成路线 （共 9 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; methanol P=2068.65 Torr;
参考文献
MERCK and CO., INC.
Patent: WO2006/20003 A2, 2006 ;
Location in patent: Page/Page column 18 ;
WO 2006/020003 A2
反应条件
potassium cyanide in tetrahydrofuran; water
参考文献
Hryhorenko, Eric; Sankaran, Banumathi; DeCory, Thomas R.; Tubbs, Theresa; Colt, Linda; Remmerie, Bart M.; Salter, Rhys; Lin, Ronghui
Patent: US2014/57299 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
in tetrahydrofuran; ethanol; water
T=0 - 20°C; 4 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2006/103559 A1, 2006 ;
Location in patent: Page/Page column 45 ;
WO 2006/103559 A1
反应条件
sodium hydride; cesium fluoride in N,N-dimethyl-formamide
T=70°C; 24 h;
参考文献
Loewe, Werner; Witzel, Sonja; Tappmeyer, Silvia; Albuschat, Rica
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 3 p. 317 - 326
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=-20 - -10°C; 0.5 h;
参考文献
Makosza, Mieczyslaw; Danikiewicz, Witold; Wojciechowski, Krzysztof
Liebigs Annalen der Chemie, 1988 , p. 203 - 208
反应条件
1: azobisisobutyronitrile; N-bromosuccinmide / tetrachloromethane
2: potassium cyanide / tetrahydrofuran; water
View Scheme
参考文献
Hryhorenko, Eric; Sankaran, Banumathi; DeCory, Thomas R.; Tubbs, Theresa; Colt, Linda; Remmerie, Bart M.; Salter, Rhys; Lin, Ronghui
Patent: US2014/57299 A1, 2014 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
1.2: 70 °C
2.1: water; sodium carbonate / 55 °C
View Scheme
参考文献
Bhattacharya, Samit K.; Cameron, Kimberly O.; Fernando, Dilinie P.; McClure, Kim F.; Kung, Daniel W.; Londregan, Allyn T.; Simila, Suvi T. M.
Patent: US2011/230461 A1, 2011 ;
US 20110230461 A1
参考文献
Doherty, James B.; Chen, Meng-Hsin; Liu, Luping; Natarajan, Swaminathan R.; Tynebor, Robert M.
Patent: US2004/97575 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
sulfuric acid in water
0.333333 h; Heating;
参考文献
Loewe, Werner; Witzel, Sonja; Tappmeyer, Silvia; Albuschat, Rica
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 3 p. 317 - 326
