N-[4-[[3-氯-4-[(3-氟苯基)甲氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯酰胺对甲苯磺酸盐合成路线 （共 4 条）
反应条件
in tetrahydrofuran; methanol; water Product distribution / selectivity;
参考文献
Guo, Jianhui; Jiang, Yong
Patent: US2012/4249 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
1: isopropyl alcohol / 3 h / Reflux 2: acetic acid; iron / methanol / 2.5 h / 85 °C 3: triethylamine / tetrahydrofuran / 3 h / 20 °C / Cooling with ice 4: water; tetrahydrofuran; methanol View Scheme
反应条件
1: isopropyl alcohol / 3 h / Reflux 2: acetic acid; iron / methanol / 2.5 h / 85 °C 3: triethylamine / tetrahydrofuran / 3 h / 20 °C / Cooling with ice 4: water; tetrahydrofuran; methanol View Scheme
反应条件
1: acetic acid; iron / methanol / 2.5 h / 85 °C 2: triethylamine / tetrahydrofuran / 3 h / 20 °C / Cooling with ice 3: water; tetrahydrofuran; methanol View Scheme
