反式-3-甲基-L-脯氨酸合成路线 （共 11 条）
反应条件
dipotassium tetrachloroplatinate; copper dichloride in water T=160°C; 10 h; Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 123, # 33 p. 8149 - 8150
反应条件
1: With hydrogenchloride in water 3 h; Reflux; 2: With ammonium hydroxide; dowex 50Wx8 in water
参考文献
Oba, Makoto; Saegusa, Tsuneki; Nishiyama, Naohiro; Nishiyama, Kozaburo
Tetrahedron, 2009 , vol. 65, # 1 p. 128 - 133
反应条件
1: 89 percent / BH3*S(CH3)2 2: 93 percent / Bu4NF 3: RuCl3, NaIO4 / acetonitrile; H2O 4: TFA View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 5, # 3 p. 351 - 354
反应条件
1: RuCl3, NaIO4 / acetonitrile; H2O 2: TFA View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 5, # 3 p. 351 - 354
反应条件
1: 93 percent / Bu4NF 2: RuCl3, NaIO4 / acetonitrile; H2O 3: TFA View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 5, # 3 p. 351 - 354
反应条件
1: 65 percent / thionyl chloride / 10 h / Heating 2: 95 percent / NaOCl / CH2Cl2; H2O / 0.83 h / 0 - 5 °C / further reagent; further solvent 3: 1) 85percent H2SO4; 2) 2N NaOH / 1) 0 deg C, 40 h irradiation; 2) 0 deg C, pH 7-7.4, then 2 h reflux in 0.24N methanolic NaOH View Scheme
参考文献
Tetrahedron, , vol. 36, p. 2961 - 2965
反应条件
1: 95 percent / NaOCl / CH2Cl2; H2O / 0.83 h / 0 - 5 °C / further reagent; further solvent 2: 1) 85percent H2SO4; 2) 2N NaOH / 1) 0 deg C, 40 h irradiation; 2) 0 deg C, pH 7-7.4, then 2 h reflux in 0.24N methanolic NaOH View Scheme
参考文献
Tetrahedron, , vol. 36, p. 2961 - 2965
反应条件
hydrogenchloride; sodium cyanoborohydride; triethylamine 1.) MeOH, 60 deg C, 72 h; 2.) ethanol, 80 deg C; 3.) methanol, r.t., 24 h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2075 - 2084
反应条件
sodium hydroxide; sulfuric acid 1) 0 deg C, 40 h irradiation; 2) 0 deg C, pH 7-7.4, then 2 h reflux in 0.24N methanolic NaOH; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 36, p. 2961 - 2965
反应条件
trifluoroacetic acid Yield given;
参考文献
Tetrahedron: Asymmetry, , vol. 5, # 3 p. 351 - 354
