6-溴-苯并[b]噻吩-2-羧酸乙酯合成路线 （共 9 条）
反应条件
1: mercapto acetic acid ethylester With sodium hydride in dimethyl sulfoxide 0.166667 h; 2: 4-Bromo-2-fluoro-benzaldehyde in dimethyl sulfoxide 0.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/92751 A2, 2007 ;
Location in patent: Page/Page column 29 ;
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=0 - 20°C; Inert atmosphere; 2: in N,N-dimethyl-formamide T=60°C; 5.5 h;
参考文献
Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Suijkerbuijk, Bart M.J.M.; Menard, Delphine; Zambon, Alfonso; Davies, Lawrence; Pons, Jean-Francois; Whittaker, Steven; Marais, Richard; Springer, Caroline J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1284 - 1304
反应条件
in ethanol 2 h; Heating;
参考文献
Dann, Otto; Char, Helmut; Fleischmann, Paul; Fricke, Helmut
Liebigs Annalen der Chemie, 1986 , # 3 p. 438 - 455
反应条件
1: Natriumacetate / acetic acid / Heating 2: NaOH / H2O / Heating 3: 42 percent / CH3ONa / bis-(2-hydroxy-ethyl) ether / 1 h / 150 - 160 °C 4: 97 percent / SOCl2 / pyridine / 3 h / Heating 5: 74 percent / ethanol / 2 h / Heating View Scheme
参考文献
Dann, Otto; Char, Helmut; Fleischmann, Paul; Fricke, Helmut
Liebigs Annalen der Chemie, 1986 , # 3 p. 438 - 455
反应条件
1: 97 percent / SOCl2 / pyridine / 3 h / Heating 2: 74 percent / ethanol / 2 h / Heating View Scheme
参考文献
Dann, Otto; Char, Helmut; Fleischmann, Paul; Fricke, Helmut
Liebigs Annalen der Chemie, 1986 , # 3 p. 438 - 455
反应条件
1: NaOH / H2O / Heating 2: 42 percent / CH3ONa / bis-(2-hydroxy-ethyl) ether / 1 h / 150 - 160 °C 3: 97 percent / SOCl2 / pyridine / 3 h / Heating 4: 74 percent / ethanol / 2 h / Heating View Scheme
参考文献
Dann, Otto; Char, Helmut; Fleischmann, Paul; Fricke, Helmut
Liebigs Annalen der Chemie, 1986 , # 3 p. 438 - 455
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=40°C; 2 h; 2: With hydrogenchloride in water pH=2;
参考文献
WO2009/39134 A1, ;
Page/Page column 159 ;
反应条件
1: potassium hydroxide / water; ethanol / 1.5 h / |Reflux 2: copper; quinoline / 2 h / 185 °C View Scheme
参考文献
Niculescu-Duvaz, Dan; Niculescu-Duvaz, Ion; Suijkerbuijk, Bart M.J.M.; Menard, Delphine; Zambon, Alfonso; Davies, Lawrence; Pons, Jean-Francois; Whittaker, Steven; Marais, Richard; Springer, Caroline J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1284 - 1304
反应条件
1: With lithium aluminium tetrahydride in diethyl ether
T=0 - 10°C; 1 h;
2: With sodium hydroxide; water in diethyl ether
参考文献
ABBOTT LABORATORIES
Patent: WO2009/39134 A1, 2009 ;
Location in patent: Page/Page column 196 ;
