3-乙酰基-N-[苄氧羰基]-O-(苄基)-L-酪氨酸甲酯合成路线 （共 8 条）
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in N,N-dimethyl-formamide T=23°C; 6 h; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Boger, Dale L.; Yohannes, Daniel
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5283 - 5286
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in N,N-dimethyl-formamide T=20°C; 6 h;
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
1: 74 percent / SOCl2 / Heating 2: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C 3: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C View Scheme
参考文献
Boger, Dale L.; Yohannes, Daniel
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5283 - 5286
反应条件
1: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C 2: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C View Scheme
参考文献
Boger, Dale L.; Yohannes, Daniel
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5283 - 5286
反应条件
1: 67 percent / AlCl3 / nitrobenzene / 6 h / 100 °C 2: 74 percent / SOCl2 / Heating 3: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C 4: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C View Scheme
参考文献
Boger, Dale L.; Yohannes, Daniel
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5283 - 5286
反应条件
1: mCPBA / CH2Cl2 / 40 °C 2: 453 mg / NH3 / CH2Cl2; methanol / 1 h 3: 61 percent / K2CO3 / dimethylformamide / 6 h / 25 °C 4: H2 / Pd/C / CH2Cl2 5: aq. Na2CO3 / acetonitrile View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
1: mCPBA / CH2Cl2 / 40 °C 2: 453 mg / NH3 / CH2Cl2; methanol / 1 h 3: H2 / Pd/C / CH2Cl2 View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
1: mCPBA / CH2Cl2 / 40 °C
2: 453 mg / NH3 / CH2Cl2; methanol / 1 h
View Scheme
参考文献
Boger, Dale L.; Yohannes, Daniel
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5283 - 5286
