5-溴-4-羟基吡啶-3-甲酸合成路线

参考文献

Ohki, Hitoshi; Ota, Masahiro; Takeuchi, Kosuke; Watanabe, Hideaki; Yamaguchi, Akitake; Shibata, Yoshihiro; Tominaga, Yuichi; Jimbo, Takeshi; Kobayashi, Keijiro; Kobayashi, Katsuhiro; Fukatsu, Daisuke
Patent: US2013/281428 A1, 2013 ;
Location in patent: Paragraph 0526; 0527 ;

109-72-8正丁基锂+

25813-25-63,5-二溴-4-羟基吡啶+

124-38-9二氧化碳

1052114-83-65-溴-4-羟基吡啶-3-甲酸

参考文献

Kyoung, Soon Kim; Zhang, Liping; Schmidt, Robert; Cai, Zhen-Wei; Wei, Donna; Williams, David K.; Lombardo, Louis J.; Trainor, George L.; Xie, Dianlin; Zhang, Yaquan; An, Yongmi; Sack, John S.; Tokarski, John S.; Darienzo, Celia; Kamath, Amrita; Marathe, Punit; Zhang, Yueping; Lippy, Jonathan; Jeyaseelan Sr., Robert; Wautlet, Barri; Henley, Benjamin; Gullo-Brown, Johnni; Manne, Veeraswamy; Hunt, John T.; Fargnoli, Joseph; Borzilleri, Robert M.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5330 - 5341

67-56-1甲醇+

1052114-83-65-溴-4-羟基吡啶-3-甲酸

1175512-08-95-溴-4-羟基烟酸甲酯

参考文献

Kyoung, Soon Kim; Zhang, Liping; Schmidt, Robert; Cai, Zhen-Wei; Wei, Donna; Williams, David K.; Lombardo, Louis J.; Trainor, George L.; Xie, Dianlin; Zhang, Yaquan; An, Yongmi; Sack, John S.; Tokarski, John S.; Darienzo, Celia; Kamath, Amrita; Marathe, Punit; Zhang, Yueping; Lippy, Jonathan; Jeyaseelan Sr., Robert; Wautlet, Barri; Henley, Benjamin; Gullo-Brown, Johnni; Manne, Veeraswamy; Hunt, John T.; Fargnoli, Joseph; Borzilleri, Robert M.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5330 - 5341