3-羟基-N-[苄氧羰基]-O-(苄基)-L-酪氨酸甲酯合成路线 （共 15 条）
反应条件
1: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C
2: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C
3: mCPBA / CH2Cl2 / 40 °C
4: 453 mg / NH3 / CH2Cl2; methanol / 1 h
View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
1: mCPBA / CH2Cl2 / 40 °C
2: 453 mg / NH3 / CH2Cl2; methanol / 1 h
View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
1: 67 percent / AlCl3 / nitrobenzene / 6 h / 100 °C
2: 74 percent / SOCl2 / Heating
3: 93 percent / aq. Na2CO3 / diethyl ether / 3 h / 25 °C
4: 60 percent / K2CO3; (n-Bu)4NI / dimethylformamide / 6 h / 20 °C
5: mCPBA / CH2Cl2 / 40 °C
6: 453 mg / NH3 / CH2Cl2; methanol / 1 h
View Scheme
参考文献
Song, Yan-Li; Peach, Megan L.; Roller, Peter P.; Qiu, Su; Wang, Shaomeng; Long, Ya-Qiu
Journal of Medicinal Chemistry, 2006 , vol. 49, # 5 p. 1585 - 1596
反应条件
1: 88 percent / Pd(dppf)Cl2*CH2Cl2; KOAc / dimethylsulfoxide / 24 h / 80 °C
2: 93 percent / H2O2 / methanol; H2O / 0.5 h / 20 °C
View Scheme
参考文献
Hunter, Luke; Hutton, Craig A.
Australian Journal of Chemistry, 2003 , vol. 56, # 11 p. 1095 - 1098
反应条件
1.1: 98 percent / K2CO3; n-Bu4NI / dimethylformamide / 1.5 h / 20 °C
2.1: m-CPBA / CH2Cl2 / 7 h / 20 °C
2.2: 85 percent / NH3 / methanol / 0.5 h / 20 °C
View Scheme
参考文献
Morera; Ortar
Synthetic Communications, 2001 , vol. 31, # 14 p. 2215 - 2222
