2-甲基-4-羟甲基吡啶合成路线 （共 17 条）
反应条件
1: With hydrogen; triethylamine; palladium 10 on activated carbon in ethyl acetate P=760.051 Torr; 21 h; 2: With hydrogen; palladium(II) hydroxide/carbon in ethyl acetate 5 h;
参考文献
Bamberg, Joe Timothy; Gabriel, Tobias; Krauss, Nancy Elisabeth; Mirzadegan, Taraneh; Palmer, Wylie Solang; Smith, David Bernard
Patent: US2004/77646 A1, 2004 ;
Location in patent: Page 116 ;
反应条件
methanol; ammonia; water T=20°C; 24 h;
参考文献
Guo, Hongyan; Kim, Choung U.; Kim, Hae Soo; Lee, Chong-Kyo; Lee, Ill Young; Mitchell, Michael L.; Son, Jong Chan; Xu, Lianhong
Patent: US2008/70920 A1, 2008 ;
Location in patent: Page/Page column 97 ;
参考文献
Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 63 ;
US 6362336 B1
反应条件
1.1: n-BuLi; Et2NH / tetrahydrofuran; hexane / 0.42 h / -50 °C 1.2: tetrahydrofuran; hexane / 1.17 h / -50 °C 2.1: aq. NaIO4 / methanol 3.1: 1.52 g / NaBH4 / methanol / 1 h View Scheme
参考文献
Synthesis, , # 4 p. 483 - 486
反应条件
sodium hydroxide in acetonitrile
参考文献
Bristol-Myers Company
Patent: US4644061 A1, 1987 ;
反应条件
lithium borohydride in tetrahydrofuran T=20°C;
参考文献
WO2010/129467 A1, ;
Page/Page column 64 ;
WO 2010/129467 A1
反应条件
1.1: triethylamine / Pd(0)(dppf)2 / N,N-dimethyl-formamide; methanol / 75 °C / Inert atmosphere 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 - 20 °C 2.2: 3 h / 0 - 20 °C View Scheme
参考文献
WO2011/38086 A2, ;
WO 2011/038086 A2
反应条件
sodium tetrahydroborate in methanol 1 h;
参考文献
Ragan, John A.; Jones, Brian P.; Meltz, Clifford N.; Teixeira Jr., John J.
Synthesis, 2002 , # 4 p. 483 - 486
反应条件
1: CH2Cl2 / 1.5 h / Ambient temperature 2: aq. (NH4)2S2O8 / 1 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 19, # 1, 2 p. 317 - 326
反应条件
acetic anhydride folgenden Erhitzen des Reaktionsgemisches mit wss.Salzsaeure;
参考文献
Pharmaceutical Bulletin, , vol. 3, p. 413,415
Yakugaku Zasshi, , vol. 76, p. 900
Chem.Abstr., , p. 2770
