2-甲基-4-羟甲基吡啶合成路线 （共 17 条）
反应条件
(NH4)2S2O8 1 h; Heating; Yield given. Yields of byproduct given;
参考文献
Synthetic Communications, , vol. 19, # 1, 2 p. 317 - 326
反应条件
anschliessend Erhitzen mit wss. Salzsaeure;
参考文献
Pharmaceutical Bulletin, , vol. 3, p. 413,415
Yakugaku Zasshi, , vol. 76, p. 900
Chem.Abstr., , p. 2770
反应条件
pyridine; chromium(VI) oxide in dichloromethane T=20°C; 0.5 h;
参考文献
PLEXXIKON, INC.; WU, Guoxian; IBRAHIM, Prabha N.; ZHOU, Yong; MAMO, Shumeye; GILLETTE, Samuel J.; ZHU, Yong-Liang; LIU, Jinyu; ZHANG, Chao; ZHANG, Kam; ARTIS, Dean R.
Patent: WO2010/129467 A1, 2010 ;
Location in patent: Page/Page column 64 ;
WO 2010/129467 A1
反应条件
in aqueous HBr; dichloromethane; acetonitrile
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US5498727 A1, 1996 ;
反应条件
1: 48percent aq. HBr / 96 h / Heating 2: H2O View Scheme
参考文献
Varney, Michael D.; Palmer, Cindy L.; Deal, Judith G.; Webber, Stephanie; Welsh, Katherine M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 11 p. 1892 - 1903
反应条件
1: With thionyl chloride in dichloromethane
T=20°C; 20 h;
2: With water; sodium hydrogencarbonate
参考文献
ASKA Pharmaceutical Co., Ltd.
Patent: EP2036905 A1, 2009 ;
Location in patent: Page/Page column 49 ;
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=20°C; 18 h;
参考文献
CHEMOCENTRYX, INC.
Patent: WO2006/76644 A2, 2006 ;
Location in patent: Page/Page column 112 ;
WO 2006/076644 A2
