4-甲基-4(对甲苯基)-2-戊酮合成路线 （共 11 条）
反应条件
aluminium trichloride T=15 - 20°C;
参考文献
Bott, Garry; Field, Leslie D.; Sternhell, Sever
Journal of the American Chemical Society, 1980 , vol. 102, # 17 p. 5618 - 5626
反应条件
potassium carbonate; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide Heck reaction; 0.0666667 h; microwave irradiation;
参考文献
Solabannavar; Desai, Uday V.; Mane
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 10 p. 2235 - 2237
反应条件
in tetrahydrofuran; hexane
参考文献
PFIZER INC.
Patent: EP1334972 A1, 2003 ;
反应条件
aluminium trichloride; toluene
参考文献
Barnes; Beitchman
Journal of the American Chemical Society, 1954 , vol. 76, p. 5430,5432
反应条件
bis(acetylacetonate)nickel(II); dimethylaluminum chloride 1) -20 deg C, 10 min, 2) THF, -20 deg C to 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Westermann, Juergen; Imbery, Ute; Nguyen, Anh Thu; Nickisch, Klaus
European Journal of Inorganic Chemistry, 1998 , # 2 p. 293 - 298
反应条件
bis(acetylacetonate)nickel(II); dimethylaluminum chloride 1) -20 deg C, 10 min, 2) THF, -20 deg C to 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Westermann, Juergen; Imbery, Ute; Nguyen, Anh Thu; Nickisch, Klaus
European Journal of Inorganic Chemistry, 1998 , # 2 p. 293 - 298
反应条件
T=0°C; Einleiten von HCl und Behandeln des gebildeten 2-Chlor-2-methyl-pentanons-(4) mit ueberschuessigem Toluol und AlCl3 bei 0grad bis 10grad;
参考文献
Colonge; Pichat
Bulletin de la Societe Chimique de France, 1949 , p. 177,183
反应条件
sodium hydroxide; bromine in 1,4-dioxane; dichloromethane; water
参考文献
PFIZER INC.
Patent: EP1334972 A1, 2003 ;
反应条件
1,4-dioxane; sodium hypochlorite; bromine weiteres Reagens: wss. NaOH;
参考文献
Bott, Garry; Field, Leslie D.; Sternhell, Sever
Journal of the American Chemical Society, 1980 , vol. 102, # 17 p. 5618 - 5626
反应条件
1: aq. H2SO4 2: CrO3, aq. H2SO4 / acetic acid / Heating 3: NaN3, aq. H2SO4 4: (i) aq. NaNO2, aq. HCl, (ii) aq. H2SO4 View Scheme
参考文献
Curtis,R.F.; Lewis,K.O.
Journal of the Chemical Society, 1962 , p. 418 - 421
