6-氟-3，4-二氢-4-氧代-2H-1-苯并吡喃-2-甲酸合成路线 （共 9 条）
反应条件
sodium hydrogencarbonate in water 0.166667 h; Heating;
参考文献
Yamaguchi; Miura; Usui; Unno; Matsumoto; Fukushima; Mizuno; Kondo; Baba; Kurono
Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 3 p. 344 - 348
反应条件
rhodium in methanol; sodium hydrogencarbonate; benzene
参考文献
Sanwa Kagaku Kenkyyusho Co., Ltd.
Patent: US5001240 A1, 1991 ;
反应条件
in hydrogenchloride; water; ethyl acetate
参考文献
Sanwa Kagaku Kenyusho Co., Ltd.
Patent: US4740517 A1, 1988 ;
反应条件
1: 80 percent / AlCl3 / 1,2-dichloro-ethane / 1 h / Heating 2: 92.1 percent / NaHCO3 / H2O / 0.17 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 44, # 3 p. 344 - 348
反应条件
1: 91.0 g / SOCl2 / 1,2-dichloro-ethane / 1 h / Heating 2: 33.4 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature 3: 85.5 percent / concd. HCl / dioxane / 2 h / Heating 4: 62.7 percent / (NH4)2CO3 / H2O / 65-70 deg C, 24 h then 90 deg C, 1 h 5: 97.1 percent / concd. H2SO4 / benzene / 5 h / Heating View Scheme
参考文献
Yamaguchi; Miura; Usui; Unno; Matsumoto; Fukushima; Mizuno; Kondo; Baba; Kurono
Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 3 p. 344 - 348
反应条件
1: 91.0 g / SOCl2 / 1,2-dichloro-ethane / 1 h / Heating 2: 33.4 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature 3: 85.5 percent / concd. HCl / dioxane / 2 h / Heating 4: 62.7 percent / (NH4)2CO3 / H2O / 65-70 deg C, 24 h then 90 deg C, 1 h View Scheme
参考文献
Yamaguchi; Miura; Usui; Unno; Matsumoto; Fukushima; Mizuno; Kondo; Baba; Kurono
Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 3 p. 344 - 348
反应条件
1: 91.0 g / SOCl2 / 1,2-dichloro-ethane / 1 h / Heating 2: 33.4 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature 3: 85.5 percent / concd. HCl / dioxane / 2 h / Heating View Scheme
参考文献
Yamaguchi; Miura; Usui; Unno; Matsumoto; Fukushima; Mizuno; Kondo; Baba; Kurono
Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 3 p. 344 - 348
反应条件
1: 91.0 g / SOCl2 / 1,2-dichloro-ethane / 1 h / Heating 2: 19.5 percent / Et3N / CH2Cl2 / 1 h / Ambient temperature 3: 92.4 percent / concd. HCl / dioxane / 2 h / Heating View Scheme
参考文献
Yamaguchi; Miura; Usui; Unno; Matsumoto; Fukushima; Mizuno; Kondo; Baba; Kurono
Arzneimittel-Forschung/Drug Research, 1994 , vol. 44, # 3 p. 344 - 348
