(R)-(-)-α-(三氟甲基)苄醇合成路线 （共 21 条）
反应条件
lipase LIP in octane T=30°C; 0.4 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 59, # 2 p. 271 - 276
反应条件
Birman's catalyst in chloroform T=28°C; 4 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 65, # 11 p. 2232 - 2238
反应条件
Birman's catalyst in chloroform T=28°C; 2 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 65, # 11 p. 2232 - 2238
反应条件
Candida antarctica in toluene 168 h; Enzymatic reaction; SolventTimeTemperature;
参考文献
Journal of Fluorine Chemistry, , vol. 154, p. 53 - 59
反应条件
1.1: N-(3,5-ditrifluoromethylbenzyl)quinidinium bromide; [1,3-bis(2,6-di-iso-propylphenyl)imidazol-2-ylidene]copper (I) fluoride / toluene / 0.17 h / -78 °C / |Inert atmosphere 1.2: -78 °C / |Inert atmosphere 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / -20 °C / |Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 47 p. 9334 - 9337
反应条件
1: p-toluenesulfonic acid monohydrate / CH2Cl2 / 1 h / Ambient temperature 2: 80 percent / p-toluenesulfonic acid / methanol / 3 h / Ambient temperature View Scheme
参考文献
Monatshefte fuer Chemie, , vol. 117, p. 407
反应条件
1: sodium tetrahydroborate / methanol / 0.75 h 2: Candida antarctica / toluene / 168 h / |Enzymatic reaction View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 154, p. 53 - 59
反应条件
tetraproline chiral stationary phase packed on HPLC column in hexane; isopropyl alcohol Resolution of racemate;
参考文献
Chirality, , vol. 24, # 4 p. 329 - 338
反应条件
sodium hydroxide Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 59, # 2 p. 271 - 276
反应条件
sodium tetrahydroborate in solid 120 h; Ambient temperatureother reducing agent and conditions; Product distribution;
参考文献
Carbohydrate Research, , vol. 192, p. 363 - 365
