顺式-2-[(1,3-二氢-1,3-二氧-2H-异吲哚-2-基)甲基-N,N-二乙基-1-苯基环丙烷甲酰胺合成路线 （共 8 条）
反应条件
in dichloromethane T=0 - 30°C; 4.75 h;
参考文献
WO2012/46247 A2, ;
Page/Page column 23 ;
反应条件
in dichloromethane T=0 - 45°C; Product distribution / selectivity;
参考文献
WO2011/158249 A1, ;
Page/Page column 24-25 ;
反应条件
1: 90 percent / SOCl2 / 2 h / Heating 2: diethyl ether / Ambient temperature 3: dimethylformamide / 2.5 h / 110 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 2 p. 318 - 325
反应条件
1.1: sodium hydride / toluene / 2 h / 10 - 20 °C 1.2: 10 - 20 °C 2.1: AlCl3, aluminium chloride / dichloromethane / 0 - 10 °C / Inert atmosphere 2.2: 1.75 h / 10 - 15 °C 3.1: thionyl chloride / dichloromethane / 1 h / 15 - 20 °C 4.1: dichloromethane / 0 - 45 °C View Scheme
反应条件
in N,N-dimethyl-formamide T=110°C; 2.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 2 p. 318 - 325
反应条件
1: diethyl ether / Ambient temperature 2: dimethylformamide / 2.5 h / 110 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 2 p. 318 - 325
反应条件
1: H2NNH2 / ethanol / Heating 2: 80 percent / pyridine / Ambient temperature View Scheme
参考文献
Bonnaud, Bernard; Cousse, Henri; Mouzin, Gilbert; Briley, Mike; Stenger, Antoine; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 318 - 325
反应条件
1: H2NNH2 / ethanol / Heating 2: Et3N / dioxane / 15 h / Ambient temperature 3: H2NNH2*H2O / ethanol / 2 h / Heating View Scheme
参考文献
Bonnaud, Bernard; Cousse, Henri; Mouzin, Gilbert; Briley, Mike; Stenger, Antoine; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 318 - 325
